Fibrillarin (Q5446439)

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mammalian protein found in Homo sapiens

histone-glutamine methyltransferase
rRNA 2'-O-methyltransferase fibrillarin
34-kD nucleolar scleroderma antigen
FBL
RNA, U3 small nucleolar interacting protein 1
34 kDa nucleolar scleroderma antigen

Language	Label	Description	Also known as
English	Fibrillarin	mammalian protein found in Homo sapiens	histone-glutamine methyltransferase rRNA 2'-O-methyltransferase fibrillarin 34-kD nucleolar scleroderma antigen FBL RNA, U3 small nucleolar interacting protein 1 34 kDa nucleolar scleroderma antigen

Statements

1 reference

13 November 2019

UniProt protein ID

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22087

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22087

Fibrillarin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

rRNA methyltransferase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

determination method

1 reference

8 April 2019

A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

histone-glutamine methyltransferase activity

determination method

1 reference

31 October 2017

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

protein binding

determination method

7 references

8 April 2019

NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

TFIID-class transcription factor complex binding

determination method

1 reference

8 April 2019

A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

determination method

6 references

31 October 2017

cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

31 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

31 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

determination method

6 references

8 April 2019

cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

small-subunit processome

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

determination method

1 reference

31 October 2017

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

determination method

8 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA.

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

dense fibrillar component

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

extracellular exosome

determination method

1 reference

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

granular component

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

fibrillar center

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

determination method

1 reference

8 April 2019

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

biological process

tRNA processing

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

snoRNA localization

determination method

1 reference

8 April 2019

A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

rRNA methylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

histone glutamine methylation

determination method

1 reference

31 October 2017

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

box C/D RNA 3'-end processing

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

sno(s)RNA metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

osteoblast differentiation

determination method

1 reference

31 October 2017

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22087&geneProductId=UniProtKB:P22087

determination method

rRNA processing

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

osteoblast differentiation

determination method

1 reference

8 April 2019

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22087

determination method

Gene Atlas image

PBB GE FBL 211623 s at fs.png
732 × 530; 12 KB

0 references

Fibrillarin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P22087

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000487390

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487390

ENSP00000221801

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000221801

ENSP00000472433

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472433

ENSP00000469249

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469249

ENSP00000472419

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472419

ENSP00000472805

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472805

ENSP00000486882

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486882

ENSP00000487026

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487026

ENSP00000486271

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486271

ENSP00000471350

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471350

ENSP00000487091

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487091

ENSP00000487170

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000487170

ENSP00000485963

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485963

ENSP00000472726

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000472726

ENSP00000469072

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469072

ENSP00000485834

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485834

ENSP00000471867

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471867

ENSP00000485785

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000485785

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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