EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex. (Q54531321)

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22 January 2020

title

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex (English)

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13

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22 January 2020

author name string

Guo Li

1

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22 January 2020

Xiao-Dan Ji

2

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Hong Gao

3

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Jiang-Sha Zhao

4

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Jun-Feng Xu

5

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Zhi-Jian Sun

6

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22 January 2020

Yue-Zhen Deng

7

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22 January 2020

Shuo Shi

8

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22 January 2020

Yu-Xiong Feng

9

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Yin-Qiu Zhu

10

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Tao Wang

11

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22 January 2020

Jing-Jing Li

12

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language of work or name

English

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publication date

7 February 2012

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22 January 2020

published in

Nature Communications

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volume

3

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22 January 2020

page(s)

667

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https://scigraph.springernature.com/pub.10.1038/ncomms1675

22 January 2020

exact match

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cites work

Receptor tyrosine kinase EphB4 is a survival factor in breast cancer

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12 December 2020

Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior

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EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

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Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness

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Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer

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A New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cells

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Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

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The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility

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12 December 2020

Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity

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12 December 2020

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins

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12 December 2020

Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer

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Curcumin disrupts the Mammalian target of rapamycin-raptor complex.

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Protein phosphatase 1--targeted in many directions

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12 December 2020

Optimization of genetics to create therapies for metastatic (stage IV) non-small-cell lung cancer

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12 December 2020

Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers

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12 December 2020

Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM.

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12 December 2020

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

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12 December 2020

A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells

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12 December 2020

Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function

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12 December 2020

EphB receptor activity suppresses colorectal cancer progression

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12 December 2020

RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints

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12 December 2020

A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis.

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12 December 2020

Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions

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12 December 2020

Eph-ephrin bidirectional signaling in physiology and disease

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12 December 2020

Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

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12 December 2020

Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome

1 reference

12 December 2020

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

1 reference

12 December 2020

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

1 reference

12 December 2020

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

1 reference

12 December 2020

Paradoxes of the EphB4 receptor in cancer

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12 December 2020

RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death

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12 December 2020

Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone

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12 December 2020

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).

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12 December 2020

Eph receptor signalling casts a wide net on cell behaviour

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12 December 2020

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration

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12 December 2020

Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.

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12 December 2020

EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration

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12 December 2020

Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses

1 reference

12 December 2020

Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.

1 reference

12 December 2020

Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1.

1 reference

12 December 2020

The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway

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12 December 2020

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

1 reference

12 December 2020

EphB/EphrinB receptors and Wnt signaling in colorectal cancer

1 reference

12 December 2020

Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells.

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12 December 2020

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

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12 December 2020

Identifiers

DOI

10.1038/NCOMMS1675

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22314363%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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