Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. (Q54558035)

31 May 2018

title

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. (English)

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31 May 2018

author

Hamish S. Scott

5

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31 May 2018

Harumi Fujita

object named as

Harumi Fujita

2

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author name string

Yoko Hamazaki

1

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31 May 2018

Takashi Kobayashi

3

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31 May 2018

Yongwon Choi

4

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31 May 2018

Mitsuru Matsumoto

6

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31 May 2018

Nagahiro Minato

7

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31 May 2018

language of work or name

English

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publication date

4 February 2007

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31 May 2018

published in

Nature Immunology

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31 May 2018

volume

8

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31 May 2018

issue

3

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31 May 2018

page(s)

304-311

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31 May 2018

Thymic generation and regeneration

cites work

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Projection of an immunological self shadow within the thymus by the aire protein

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Multifunctional strands in tight junctions

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Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

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Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.

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NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

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Dependence of self-tolerance on TRAF6-directed development of thymic stroma

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

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Self-representation in the thymus: an extended view

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

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Positional cloning of the APECED gene

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Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

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T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form

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Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

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Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression.

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Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice

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Thymus medulla consisting of epithelial islets each derived from a single progenitor

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Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

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Lymphotoxin pathway directs thymic Aire expression

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Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.

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Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

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Expression of relB is required for the development of thymic medulla and dendritic cells

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Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

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A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts

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TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

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Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.

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Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

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Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

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Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin

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Analysis of thymic stromal cell populations using flow cytometry

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21 January 2018

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7 January 2021

Identification and Characterization of Thymic Epithelial Progenitor Cells

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7 January 2021

Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells

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7 January 2021

Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage

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7 January 2021

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

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7 January 2021

Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI1438

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31 May 2018

Dimensions Publication ID

1012293606

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31 May 2018