S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. (Q54561835)

1 June 2018

title

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. (English)

1 reference

1 June 2018

main subject

myocardial infarction

1 reference

1 reference

8

Brian A Hemmings

1 reference

1 June 2018

author name string

Ruomin Di

1

1 reference

1 June 2018

Xiangqi Wu

2

1 reference

1 June 2018

Zai Chang

3

1 reference

1 June 2018

Xia Zhao

4

1 reference

1 June 2018

Qiuting Feng

5

1 reference

1 June 2018

Shuangshuang Lu

6

1 reference

1 June 2018

Qing Luan

7

1 reference

1 June 2018

Xinli Li

9

1 reference

1 June 2018

Zhongzhou Yang

10

1 reference

1 June 2018

language of work or name

English

0 references

publication date

1 January 2012

1 reference

1 June 2018

published in

Biochemical Journal

1 reference

1 June 2018

volume

441

1 reference

1 June 2018

issue

1

1 reference

1 June 2018

page(s)

199-207

1 reference

1 June 2018

Myocardial infarct size and ventricular function in rats

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

mTOR signaling at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Tubers and tumors: rapamycin therapy for benign and malignant tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

mTOR and the control of whole body metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

mTORC2 Caught in a SINful Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Optimal targeting of the mTORC1 kinase in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

mTOR-targeted therapy of cancer with rapamycin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Analysis of 1-year clinical outcomes in the SIRIUS trial: a randomized trial of a sirolimus-eluting stent versus a standard stent in patients at high risk for coronary restenosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Rapamycin attenuates load-induced cardiac hypertrophy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Rapamycin in transplantation: a review of the evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Protein kinase B alpha/Akt1 regulates placental development and fetal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Advances in protein kinase B signalling: AKTion on multiple fronts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Hypothalamic mTOR signaling regulates food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Defining the role of mTOR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

PDK1, the master regulator of AGC kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

PDK1 coordinates survival pathways and beta-adrenergic response in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Akt/protein kinase B promotes organ growth in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Akt2 regulates cardiac metabolism and cardiomyocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110033

21 January 2018

Identifiers

DOI

10.1042/BJ20110033

1 reference

1 June 2018

1 reference

1 June 2018