Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). (Q39668305)

13 September 2017

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). (English)

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13 September 2017

Laura R Pearce

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Dario Alessi

object named as

Dario R Alessi

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author name string

Gordon R Alton

2

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13 September 2017

Daniel T Richter

3

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13 September 2017

John C Kath

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13 September 2017

Laura Lingardo

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13 September 2017

Justin Chapman

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13 September 2017

Catherine Hwang

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13 September 2017

language of work or name

English

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publication date

1 October 2010

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13 September 2017

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13 September 2017

431

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13 September 2017

2

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13 September 2017

245-255

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The nuts and bolts of AGC protein kinases

13 September 2017

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https://api.crossref.org/works/10.1042%2FBJ20101024

Drosophila S6 kinase: a regulator of cell size

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Rictor is a novel target of p70 S6 kinase-1.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Amino acid regulation of TOR complex 1.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

GSK3 takes centre stage more than 20 years after its discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Inhibitor hijacking of Akt activation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Characterization of S6K2, a novel kinase homologous to S6K1

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

SKAR is a specific target of S6 kinase 1 in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20101024

Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20101024

21 January 2018

Identifiers

DOI

10.1042/BJ20101024

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13 September 2017

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