TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier. (Q54610673)

1 June 2018

title

TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier. (English)

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3

Emma Guttman-Yassky

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James G. Krueger

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object named as

James G Krueger

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Irma R Cardinale

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object named as

Irma R Cardinale

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Patricia M Gilleaudeau

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object named as

Patricia M Gilleaudeau

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author name string

Byung Eui Kim

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Michael D Howell

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Mark Boguniewicz

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Donald Y M Leung

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language of work or name

English

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publication date

24 February 2011

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Journal of Investigative Dermatology

published in

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volume

131

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issue

6

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page(s)

1272-1279

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https://scigraph.springernature.com/pub.10.1038/jid.2011.24

exact match

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cites work

IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.

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The cornified envelope: a model of cell death in the skin

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Mammalian MAP kinase signalling cascades

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Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis

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Contrasting disease patterns in psoriasis and atopic dermatitis

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TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein

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Elevated tumour necrosis factor-alpha (TNF-alpha) biological activity in psoriatic skin lesions

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Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis

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Cytokine modulation of atopic dermatitis filaggrin skin expression

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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Loss-of-Function Variants of the Filaggrin Gene Are Not Major Susceptibility Factors for Psoriasis Vulgaris or Psoriatic Arthritis in German Patients

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Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

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Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor

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Activation of the JNK signaling pathway: breaking the brake on apoptosis

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Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes

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Endogenous antimicrobial peptides and skin infections in atopic dermatitis

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The skin: an indispensable barrier

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Update on the natural history and systemic treatment of psoriasis

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IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation

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Terminal differentiation of epidermal keratinocytes

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Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

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Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes

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Activation and signaling of the p38 MAP kinase pathway

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7 January 2021

Identifiers

DOI

10.1038/JID.2011.24

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1 June 2018

PubMed ID

21346775

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1 June 2018