Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. (Q54643915)

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English	Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases.	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

author name string

D W Hein

1

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Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

T D Rustan

2

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

R J Ferguson

3

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

M A Doll

4

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

K Gray

5

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

publication date

1 January 1994

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Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

Archives of Toxicology

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Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

68

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Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

2

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Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

129-133

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

Molecular mechanism of slow acetylation of drugs and carcinogens in humans

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Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression

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Regulation of ribosomal RNA promoters with a synthetic lac operator

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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

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N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells

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Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

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The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)

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DNA sequencing with chain-terminating inhibitors

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Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

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Diverse point mutations in the human gene for polymorphic N-acetyltransferase

1 reference

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Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors

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Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179482

12 December 2020

based on heuristic

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Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver

1 reference

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12 December 2020

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Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2

1 reference

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Detection of 2-amino-3-methylimidazo[4,5-f]quinoline in cigarette smoke condensate

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New environmental carcinogens in daily life

1 reference

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32P Postlabelling analysis of urinary mutagens from smokers of black tobacco implicates 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) as a major DNA-damaging agent

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Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver

1 reference

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based on heuristic

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Aromatic amine acetyltransferase as a marker for colorectal cancer: environmental and demographic associations

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Role of aromatic amine acetyltransferase in human colorectal cancer

1 reference

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Acetylator genotype and arylamine-induced carcinogenesis

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Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.

1 reference

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Acetylation phenotype in colorectal carcinoma

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Metabolic polymorphisms affecting activation of toxic and mutagenic arylamines

1 reference

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Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants.

1 reference

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N-acetylation pharmacogenetics

1 reference

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Monomorphic and polymorphic isozymes of arylamine N-acetyltransferases in hamster liver: purification of the isozymes and genetic basis of N-acetylation polymorphism

1 reference

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Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase

1 reference

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Purification and biochemical characterization of hepatic arylamine N-acetyltransferase from rapid and slow acetylator mice: identity with arylhydroxamic acid N,O-acyltransferase and N-hydroxyarylamine O-acetyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179482

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Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver

1 reference

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Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines

1 reference

https://pubmed.ncbi.nlm.nih.gov/8179482

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1007/S002040050045

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 June 2018

http://europepmc.org/abstract/MED/8179482

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