Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma. (Q54657102)

2 June 2018

title

Absence of gain-of-function JAK1 and JAK3 mutations in adult T cell leukemia/lymphoma. (English)

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2 June 2018

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T Kameda

1

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K Shide

2

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H K Shimoda

3

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T Hidaka

4

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Y Kubuki

5

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K Katayose

6

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Y Taniguchi

7

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M Sekine

8

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A Kamiunntenn

9

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K Maeda

10

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K Nagata

11

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T Matsunaga

12

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K Shimoda

13

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publication date

10 August 2010

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International Journal of Hematology

published in

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volume

92

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issue

2

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page(s)

320-325

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https://scigraph.springernature.com/pub.10.1007/s12185-010-0653-2

exact match

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cites work

The JAK-STAT signaling pathway: input and output integration

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Janus kinases in immune cell signaling

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Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

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Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers

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Inactivation of tumor suppressor genes and the progression of adult T-cell leukemia-lymphoma

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Loss-of-function JAK3 mutations in TMD and AMKL of Down syndrome

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Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells

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Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

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Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses

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Multiple gammac-receptor expression in adult T-cell leukemia.

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A haplotype map of the human genome

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Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma

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Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

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Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome

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Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

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Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

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Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

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Leukaemogenic mechanism of human T-cell leukaemia virus type I.

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Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

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Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

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Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo

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Fas 670 promoter polymorphism is associated to susceptibility, clinical presentation, and survival in adult T cell leukemia.

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Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

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12 December 2020

Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation

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Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.

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Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.

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12 December 2020

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

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JAK3 Janus kinase is involved in interleukin 7 signal pathway

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Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

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Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87).

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Identification of somatic JAK1 mutations in patients with acute myeloid leukemia

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NF-kappaB in pathogenesis and treatment of adult T-cell leukemia/lymphoma

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Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

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Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

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The International HapMap Project

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Activating alleles of JAK3 in acute megakaryoblastic leukemia

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Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia

1 reference

12 December 2020

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

1 reference

12 December 2020

10.1007/S12185-010-0653-2

Identifiers

DOI

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2 June 2018

PubMed ID

20697856

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2 June 2018