Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells. (Q54705317)

3 June 2018

title

Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells. (English)

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3 June 2018

author name string

Jing Li

1

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3 June 2018

Meixiang Xu

2

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3 June 2018

Zhen Yang

3

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3 June 2018

Albert Li

4

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3 June 2018

Jianli Dong

5

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3 June 2018

publication date

1 May 2010

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3 June 2018

published in

Cancer Investigation

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3 June 2018

volume

28

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3 June 2018

issue

4

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3 June 2018

page(s)

350-356

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3 June 2018

Malignant melanoma in the 21st century: the emerging molecular landscape

cites work

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

BRAF(E600) in benign and malignant human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

The MAPK pathway in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Rb/E2F: a two-edged sword in the melanocytic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

The regulation of INK4/ARF in cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

How to make a melanoma: what do we know of the primary clonal events?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Distinct sets of genetic alterations in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Melanoma cell autonomous growth: the Rb/E2F pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

The Bcl-2 apoptotic switch in cancer development and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F07357900903286966

10.1080/07357900903286966

21 January 2018

Identifiers

DOI

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3 June 2018

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3 June 2018