Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice. (Q54782198)

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18 January 2020

title

Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice (English)

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18 January 2020

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5

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18 January 2020

6

R A Flavell

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18 January 2020

7

R J Davis

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18 January 2020

author name string

A K H Lim

1

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18 January 2020

D J Nikolic-Paterson

2

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18 January 2020

F Y Ma

3

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18 January 2020

E Ozols

4

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18 January 2020

G H Tesch

8

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18 January 2020

publication date

9 December 2008

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18 January 2020

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18 January 2020

volume

52

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18 January 2020

issue

2

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18 January 2020

page(s)

347-358

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Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy

18 January 2020

cites work

1 reference

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Apoptosis in podocytes induced by TGF-beta and Smad7

21 January 2018

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MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy

21 January 2018

1 reference

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Apoptosis in the kidneys of patients with type II diabetic nephropathy

21 January 2018

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12 December 2020

Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor

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12 December 2020

Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase

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12 December 2020

p38 mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis

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12 December 2020

Advanced glycation endproducts: activators of cardiac remodeling in primary fibroblasts from adult rat hearts

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12 December 2020

Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells

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12 December 2020

High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogen-activated protein kinase pathway in rat kidney proximal tubular cells

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12 December 2020

p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury

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12 December 2020

Angiotensin II stimulates the synthesis of vascular endothelial growth factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytes.

1 reference

12 December 2020

Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes

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12 December 2020

Role of mitogen-activated protein kinase in the regulation of transforming growth factor-beta-induced fibronectin accumulation in cultured renal interstitial fibroblasts

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12 December 2020

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.

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12 December 2020

Correlations of tissue macrophages and cytoskeletal protein expression with renal fibrosis in patients with diabetes mellitus.

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12 December 2020

Activation and signaling of the p38 MAP kinase pathway

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12 December 2020

Stimulation of pro-alpha(1)(I) collagen by TGF-beta(1) in mesangial cells: role of the p38 MAPK pathway

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12 December 2020

Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus.

1 reference

12 December 2020

Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy

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12 December 2020

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney

1 reference

12 December 2020

Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells

1 reference

12 December 2020

Molecular understanding of hyperglycemia's adverse effects for diabetic complications

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12 December 2020

Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

1 reference

12 December 2020

Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes

1 reference

12 December 2020

The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis

1 reference

12 December 2020

Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway

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12 December 2020

Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6

1 reference

12 December 2020

Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells

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12 December 2020

High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells

1 reference

12 December 2020

The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice.

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12 December 2020

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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12 December 2020

Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis

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12 December 2020

ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells

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12 December 2020

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

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12 December 2020

p38 MAP-kinases pathway regulation, function and role in human diseases

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12 December 2020

FR167653 inhibits fibronectin expression and apoptosis in diabetic glomeruli and in high-glucose-stimulated mesangial cells

1 reference

12 December 2020

TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes.

1 reference

12 December 2020

Activation of the glucose transporter GLUT4 by insulin

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12 December 2020

Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression

1 reference

12 December 2020

Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

1 reference

12 December 2020

p38MAP Kinase activity is required for human primary adipocyte differentiation

1 reference

12 December 2020

Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages

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12 December 2020

MKK6/3 and p38 MAPK pathway activation is not necessary for insulin-induced glucose uptake but regulates glucose transporter expression

1 reference

12 December 2020

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice

1 reference

12 December 2020

Podocyte loss and progressive glomerular injury in type II diabetes

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12 December 2020

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

1 reference

12 December 2020

Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.

1 reference

12 December 2020

MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model

1 reference

12 December 2020

Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis

1 reference

12 December 2020