The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. (Q55069844)

16 June 2018

title

The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model. (English)

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16 June 2018

main subject

pp-242

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ChEBI release 2020-05-28

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Xiaohua Zhang

1

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16 June 2018

Xianjin Wang

2

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16 June 2018

Liang Qin

3

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16 June 2018

Tianyuan Xu

4

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16 June 2018

Zhaowei Zhu

5

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16 June 2018

Shan Zhong

6

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16 June 2018

Minguang Zhang

7

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16 June 2018

Zhoujun Shen

8

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16 June 2018

language of work or name

English

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publication date

6 November 2014

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16 June 2018

published in

Urology

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16 June 2018

volume

85

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16 June 2018

issue

1

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16 June 2018

page(s)

273.e1-7

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16 June 2018

Rationale for anti-angiogenic therapy in pheochromocytoma and paraganglioma.

cites work

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Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

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Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.

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Interferon alpha and rapamycin inhibit the growth of pheochromocytoma PC12 line in vitro

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7 January 2021

Identifiers

DOI

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16 June 2018

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16 June 2018