mTOR kinase inhibitors as potential cancer therapeutic drugs (Q27027963)

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language of work or name

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28 October 2013

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340

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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

21 March 2017

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Targeting phosphoinositide 3-kinase: moving towards therapy

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Defining the role of mTOR in cancer

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 March 2017

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

7 April 2017

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

7 April 2017

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

7 April 2017

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mTOR and cancer: insights into a complex relationship

7 April 2017

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

7 April 2017

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The TOR pathway: a target for cancer therapy

7 April 2017

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Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

7 April 2017

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Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models.

28 September 2017

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Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia

28 September 2017

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Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphoma

28 September 2017

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Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

28 September 2017

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The use of agonistic anti-CD40 therapy in treatments for cancer

28 September 2017

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The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and

28 September 2017

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Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy

28 September 2017

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Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

28 September 2017

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

28 September 2017

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Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

28 September 2017

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

28 September 2017

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Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

28 September 2017

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Defining the role of TORC1/2 in multiple myeloma

28 September 2017

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Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1

28 September 2017

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Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo

28 September 2017

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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin

28 September 2017

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mTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment

28 September 2017

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Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors

28 September 2017

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PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs

28 September 2017

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Initial testing (stage 1) of the mTOR kinase inhibitor AZD8055 by the pediatric preclinical testing program

28 September 2017

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Everolimus for advanced pancreatic neuroendocrine tumors.

28 September 2017

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Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.

28 September 2017

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Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

28 September 2017

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Recent advances in the development of selective, ATP-competitive inhibitors of mTOR.

28 September 2017

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Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment

28 September 2017

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Novel inhibitors of mTORC1 and mTORC2.

28 September 2017

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Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

28 September 2017

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Enhancing mTOR-targeted cancer therapy

28 September 2017

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Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin

28 September 2017

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

28 September 2017

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A phase 2 study with a daily regimen of the oral mTOR inhibitor RAD001 (everolimus) in patients with metastatic clear cell renal cell cancer

28 September 2017

1 reference

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Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy

28 September 2017

1 reference

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

28 September 2017

1 reference

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Targeting the mTOR signaling network in cancer.

28 September 2017

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The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy

28 September 2017

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

28 September 2017

1 reference

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Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

28 September 2017

1 reference

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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

31 May 2018

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Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.

31 May 2018

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Safety and tolerability of AZD8055 in Japanese patients with advanced solid tumors; a dose-finding phase I study.

28 November 2018

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Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).

28 November 2018

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The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3779533

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3779533

New insights into mTOR signaling: mTORC2 and beyond

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3779533

The pharmacology of mTOR inhibition

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3779533

mTORC2 is the hydrophobic motif kinase for SGK1.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3779533

The inhibition of MAPK potentiates the anti-angiogenic efficacy of mTOR inhibitors

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23792225