Geminin DNA replication inhibitor (Q5530676)

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mammalian protein found in Homo sapiens

• GMNN
• geminin
• uniprot:O75496

edit

Language	Label	Description	Also known as
English	Geminin DNA replication inhibitor	mammalian protein found in Homo sapiens	GMNN geminin uniprot:O75496

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O75496

part of

Geminin

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O75496

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O75496

encoded by

GMNN

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O75496

molecular function

histone deacetylase binding

determination method

IPI

1 reference

retrieved

8 April 2019

stated in

A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

protein binding

determination method

IPI

15 references

retrieved

8 April 2019

stated in

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

A WD-repeat protein stabilizes ORC binding to chromatin

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Self-assembling protein microarrays

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

retrieved

8 April 2019

stated in

JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IPI

transcription corepressor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

chromatin binding

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

cell component

cytoplasm

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

nucleus

determination method

IDA

IEA

5 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

retrieved

8 April 2019

stated in

The histone demethylase LSD1/KDM1A promotes the DNA damage response

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

nucleoplasm

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

TAS

cytosol

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

biological process

animal organ morphogenesis

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

cell cycle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

negative regulation of cell cycle

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

Geminin, an inhibitor of DNA replication, is degraded during mitosis

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

negative regulation of DNA replication

determination method

IDA

IEA

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

Geminin, an inhibitor of DNA replication, is degraded during mitosis

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

negative regulation of transcription, DNA-templated

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

retrieved

8 April 2019

stated in

A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

regulation of DNA replication

determination method

IEA

1 reference

retrieved

24 April 2018

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75496&geneProductId=UniProtKB:O75496

determination method

IEA

positive regulation of chromatin binding

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

DNA replication preinitiation complex assembly

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

negative regulation of DNA-dependent DNA replication

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Inhibition of eukaryotic DNA replication by geminin binding to Cdt1

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IDA

protein-containing complex assembly

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

G1/S transition of mitotic cell cycle

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

TAS

regulation of DNA replication

determination method

IEA

IMP

2 references

retrieved

8 April 2019

stated in

The APC/C inhibitor, Emi1, is essential for prevention of rereplication

GOA

curator

UniProt

UniProt protein ID

O75496

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IMP

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75496

determination method

IEA

Gene Atlas image

PBB GE GMNN 218350 s at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/O75496

1 reference

stated in

Identifiers.org

Identifiers

RefSeq protein ID

NP_001238918

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

51053

NP_001238919

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

51053

NP_001238920

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

51053

NP_056979

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

51053

XP_005249216

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

51053

XP_011512953

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

51053

UniProt protein ID

O75496

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

O75496

Ensembl protein ID

ENSP00000230056

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000230056

ENSP00000348902

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000348902

ENSP00000477506

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000477506

ENSP00000367293

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000367293

ENSP00000367298

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000367298

ENSP00000419584

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000419584

Freebase ID

/m/0h78fj

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1T6F

1 reference

stated in

UniProt

UniProt protein ID

O75496

retrieved

9 August 2016

language of work or name

English

1UII

1 reference

stated in

UniProt

UniProt protein ID

O75496

retrieved

9 August 2016

language of work or name

English

2LP0

1 reference

stated in

UniProt

UniProt protein ID

O75496

retrieved

9 August 2016

language of work or name

English

2WVR

1 reference

stated in

UniProt

UniProt protein ID

O75496

retrieved

9 August 2016

language of work or name

English

4BRY

1 reference

stated in

UniProt

UniProt protein ID

O75496

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q5530676&oldid=2022908072"