The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? (Q56453443)

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28 March 2020

title

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? (English)

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1

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4

John H Krystal

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3

Ronald S Duman

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2

Gerard Sanacora

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publication date

25 May 2018

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Pharmacology & Therapeutics

28 March 2020

published in

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volume

190

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28 March 2020

page(s)

148-158

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Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

28 March 2020

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Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

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A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression

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GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.

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Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment

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Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial

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Common Neurotransmission Recruited in (R,S)-Ketamine and (2R,6R)-Hydroxynorketamine-Induced Sustained Antidepressant-like Effects.

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Ketamine for the treatment of addiction: Evidence and potential mechanisms.

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Mapping the central effects of (±)-ketamine and traxoprodil using pharmacological magnetic resonance imaging in awake rats

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12 December 2020

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression.

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12 December 2020

Preclinical and Clinical Evidence of DNA Methylation Changes in Response to Trauma and Chronic Stress

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The Neurobiological Mechanisms of Generalized Anxiety Disorder and Chronic Stress

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Chronic Stress in Adolescents and Its Neurobiological and Psychopathological Consequences: An RDoC Perspective

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The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder

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Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study.

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Efficacy, Safety, and Durability of Repeated Ketamine Infusions for Comorbid Posttraumatic Stress Disorder and Treatment-Resistant Depression.

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Altered Cortical GABA in Female Veterans with Suicidal Behavior: Sex Differences and Clinical Correlates

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Neurobiology of Chronic Stress-Related Psychiatric Disorders: Evidence from Molecular Imaging Studies

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Early Life Stress Associated With Increased Striatal -Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass and Behavioral Correlates

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Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action.

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12 December 2020

10.1016/J.PHARMTHERA.2018.05.010

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29803629%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29803629%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PubMed publication ID

29803629

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