Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease (Q56907596)

Journal of Neuroimmunology

Europe PubMed Central

title

Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease (English)

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N J Karandikar

1

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C L Vanderlugt

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2

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J A Bluestone

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3

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S D Miller

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4

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language of work or name

English

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publication date

14 August 1998

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published in

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volume

89

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issue

1-2

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page(s)

10-8

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cites work

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CTLA4 mediates antigen-specific apoptosis of human T cells

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CD80 costimulation is essential for the induction of airway eosinophilia

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Identification of an alternative CTLA-4 ligand costimulatory for T cell activation

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T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

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CTLA-4 can function as a negative regulator of T cell activation

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CTLA-4 ligation blocks CD28-dependent T cell activation

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CTLA-4-B7 interaction is sufficient to costimulate T cell clonal expansion

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