CLC Chloride Channels and Transporters: From Genes to Protein Structure, Pathology and Physiology (Q56974917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18307107%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

review article

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title

CLC chloride channels and transporters: from genes to protein structure, pathology and physiology (English)

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3 January 2020

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3 January 2020

author name string

Thomas J. Jentsch

series ordinal

1

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publication date

1 January 2008

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Critical Reviews in Biochemistry and Molecular Biology

3 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18307107%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

43

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3 January 2020

page(s)

3-36

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3 January 2020

issue

1

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Synergism between halide binding and proton transport in a CLC-type exchanger.

3 January 2020

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Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels.

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Conformational changes in the pore of CLC-0.

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Separate ion pathways in a Cl-/H+ exchanger

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Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension

21 January 2018

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The structure of a domain common to archaebacteria and the homocystinuria disease protein

21 January 2018

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Completely functional double-barreled chloride channel expressed from a single Torpedo cDNA

21 January 2018

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Molecular basis for decreased muscle chloride conductance in the myotonic goat

21 January 2018

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Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP.

21 January 2018

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Temperature dependence of human muscle ClC-1 chloride channel

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Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels

21 January 2018

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Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure

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Leukoencephalopathy upon disruption of the chloride channel ClC-2.

21 January 2018

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

21 January 2018

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Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein

21 January 2018

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Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption

21 January 2018

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Exterior site occupancy infers chloride-induced proton gating in a prokaryotic homolog of the ClC chloride channel

21 January 2018

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ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family

21 January 2018

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Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter

21 January 2018

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Chloride conductance in normal and myotonic muscle fibres and the action of monocarboxylic aromatic acids

21 January 2018

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Evidence for the intracellular location of chloride channel (ClC)-type proteins: co-localization of ClC-6a and ClC-6c with the sarco/endoplasmic-reticulum Ca2+ pump SERCA2b

21 January 2018

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Expression of human pICln and ClC-6 in Xenopus oocytes induces an identical endogenous chloride conductance.

21 January 2018

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Large movement in the C terminus of CLC-0 chloride channel during slow gating

21 January 2018

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Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers.

21 January 2018

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Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride.

21 January 2018

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Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human

21 January 2018

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https://api.crossref.org/works/10.1080%2F10409230701829110

Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing

21 January 2018

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Different fast-gate regulation by external Cl(-) and H(+) of the muscle-type ClC chloride channels

21 January 2018

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Structure and function of clc channels

21 January 2018

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Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel

21 January 2018

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Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

21 January 2018

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https://api.crossref.org/works/10.1080%2F10409230701829110

Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene

21 January 2018

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Mechanism of anionic conduction across ClC

21 January 2018

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Mutational scanning of potassium, sodium and chloride ion channels in malignant migrating partial seizures in infancy.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10409230701829110

Conduction mechanisms of chloride ions in ClC-type channels

21 January 2018

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https://api.crossref.org/works/10.1080%2F10409230701829110

SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mutations and polymorphisms of the CLCN2 gene in idiopathic epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channels

21 January 2018

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Quantitative analysis of the voltage-dependent gating of mouse parotid ClC-2 chloride channel

21 January 2018

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Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+.

21 January 2018

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Altered gating and regulation of a carboxy-terminal ClC channel mutant expressed in the Caenorhabditis elegans oocyte.

21 January 2018

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Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease

21 January 2018

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Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex

21 January 2018

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https://api.crossref.org/works/10.1080%2F10409230701829110

Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels

21 January 2018

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https://api.crossref.org/works/10.1080%2F10409230701829110

Activation by acidic pH of CLC-7 expressed in oocytes from Xenopus laevis

21 January 2018

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Molecular identification of a volume-regulated chloride channel

21 January 2018

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Involvement of helices at the dimer interface in ClC-1 common gating

21 January 2018

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A structural perspective on ClC channel and transporter function

21 January 2018

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X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

21 January 2018

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Gating the selectivity filter in ClC chloride channels

21 January 2018

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Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific

21 January 2018

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Towards prediction of cognate complexes between the WW domain and proline-rich ligands

21 January 2018

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Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The mechanism of fast-gate opening in ClC-0.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The role of a conserved lysine in chloride- and voltage-dependent ClC-0 fast gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Functional and structural conservation of CBS domains from CLC chloride channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1.

21 January 2018

1 reference

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Pore-forming segments in voltage-gated chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Electrostatics of ion stabilization in a ClC chloride channel homologue from Escherichia coli.

21 January 2018

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Mouse models and the urinary concentrating mechanism in the new millennium

21 January 2018

1 reference

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Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Influence of gain of function epithelial chloride channel ClC-Kb mutation on hearing thresholds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents.

21 January 2018

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The yeast CLC chloride channel functions in cation homeostasis

21 January 2018

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The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins

21 January 2018

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ClC-3-independent, PKC-dependent activity of volume-sensitive Cl channel in mouse ventricular cardiomyocytes

21 January 2018

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The GEF1 gene of Saccharomyces cerevisiae encodes an integral membrane protein; mutations in which have effects on respiration and iron-limited growth.

21 January 2018

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Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume

21 January 2018

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Mechanisms of disease: what can mouse models tell us about the molecular processes underlying Dent disease?

21 January 2018

1 reference

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ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells

21 January 2018

1 reference

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The ClC-5 chloride channel knock-out mouse - an animal model for Dent's disease.

21 January 2018

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Absence of the skeletal muscle sarcolemma chloride channel ClC-1 in myotonic mice

21 January 2018

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Impaired acidification in early endosomes of ClC-5 deficient proximal tubule

21 January 2018

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ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

21 January 2018

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Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies

21 January 2018

1 reference

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Molecular mechanisms of Bartter syndrome caused by mutations in the BSND gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity

21 January 2018

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The role of the carboxyl terminus in ClC chloride channel function

21 January 2018

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Anion permeation in human ClC-4 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Megalin antagonizes activation of the parathyroid hormone receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Membrane cholesterol content modulates ClC-2 gating and sensitivity to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Association between Hsp90 and the ClC-2 chloride channel upregulates channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds. Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5.

21 January 2018

1 reference

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Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells

21 January 2018

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Relevance of the D13 region to the function of the skeletal muscle chloride channel, ClC-1.

21 January 2018

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Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines.

21 January 2018

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Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase

21 January 2018

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Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte

21 January 2018

1 reference

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Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

CBS domains: structure, function, and pathology in human proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Activating mutation of the renal epithelial chloride channel ClC-Kb, predisposing to hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Chloride and the endosomal-lysosomal pathway: emerging roles of CLC chloride transporters.

21 January 2018

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https://api.crossref.org/works/10.1080%2F10409230701829110

Physiological functions of CLC Cl- channels gleaned from human genetic disease and mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Molecular dissection of gating in the ClC-2 chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Two highly homologous members of the ClC chloride channel family in both rat and human kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The skeletal muscle chloride channel in dominant and recessive human myotonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Polymorphisms in the CLCN7 gene modulate bone density in postmenopausal women and in patients with autosomal dominant osteopetrosis type II

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mutations in the a3 subunit of the vacuolar H(+)-ATPase cause infantile malignant osteopetrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Yeast mutants affecting possible quality control of plasma membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Elimination of the slow gating of ClC-0 chloride channel by a point mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Distribution of ClC-2 chloride channel in rat and human epithelial tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Sodium, Potassium, and Chloride Fluxes in Intercostal Muscle from Normal Goats and Goats with Hereditary Myotonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Cable parameters, sodium, potassium, chloride, and water content, and potassium efflux in isolated external intercostal muscle of normal volunteers and patients with myotonia congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A common molecular basis for three inherited kidney stone diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Ion-binding properties of the ClC chloride selectivity filter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Heteromultimeric CLC chloride channels with novel properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Two physically distinct pores in the dimeric ClC-0 chloride channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Functional evaluation of Dent's disease-causing mutations: implications for ClC-5 channel trafficking and internalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Formation of CLC-0 chloride channels from separated transmembrane and cytoplasmic domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Clinical and cellular manifestations of OSTM1-related infantile osteopetrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

ClC-5 does not affect megalin expression and function in the thyroid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Acidification of the endocytic and exocytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Homodimeric architecture of a ClC-type chloride ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

ClC chloride channels viewed through a transporter lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The chloride channel ClC-4 co-localizes with cystic fibrosis transmembrane conductance regulator and may mediate chloride flux across the apical membrane of intestinal epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The Chloride Channel ClC-4 Contributes to Endosomal Acidification and Trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Uncoupling of a CLC Cl-/H+ exchange transporter by polyatomic anions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A Conserved Pore‐Lining Glutamate as a Voltage‐ and Chloride‐Dependent Gate in the ClC‐2 Chloride Channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Properties of volume-regulated anion channels in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Characteristics of the chloride conductance in muscle fibers of the rat diaphragm

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mutations in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Regulated sarcolemmal localization of the muscle-specific ClC-1 chloride channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Comparison of voltage-activated Cl- channels in rat parotid acinar cells with ClC-2 in a mammalian expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Basolateral localization of native ClC-2 chloride channels in absorptive intestinal epithelial cells and basolateral sorting encoded by a CBS-2 domain di-leucine motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Polymorphisms of the CLCN7 gene are associated with BMD in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Molecular determinants of differential pore blocking of kidney CLC-K chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Identification of novel human WW domain-containing proteins by cloning of ligand targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Lysosomal storage disease upon disruption of the neuronal chloride transport protein ClC-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Identification of homer as a homologue of the Wiskott-Aldrich syndrome protein suggests a receptor-binding function for WH1 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Structural insights into chloride and proton-mediated gating of CLC chloride channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Chloride dependence of hyperpolarization-activated chloride channel gates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Temperature dependence of fast and slow gating relaxations of ClC-0 chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Low single channel conductance of the major skeletal muscle chloride channel, ClC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Severe malignant osteopetrosis caused by a GL gene mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Identification of a novel mutation in the coding region of the grey-lethal gene OSTM1 in human malignant infantile osteopetrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Steady-state coupling of ion-channel conformations to a transmembrane ion gradient

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Regulation of the human skeletal muscle chloride channel hClC-1 by protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

CLH-3, a ClC-2 anion channel ortholog activated during meiotic maturation in C. elegans oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Concentration and pH dependence of skeletal muscle chloride channel ClC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Immunolocalization of ClC-K chloride channel in strial marginal cells and vestibular dark cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Cell volume regulation and swelling-activated chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The role of chloride channels in osteoclasts: ClC-7 as a target for osteoporosis treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

X-linked hypercalciuric nephrolithiasis: clinical syndromes and chloride channel mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Salt wasting and deafness resulting from mutations in two chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Reconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Transmembrane topology of a CLC chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Barttin modulates trafficking and function of ClC-K channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

CLC chloride channels in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

KCNE1 mutations cause jervell and Lange-Nielsen syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

An internalization signal in ClC-5, an endosomal Cl-channel mutated in dent's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Golgi localization and functionally important domains in the NH2 and COOH terminus of the yeast CLC putative chloride channel Gef1p

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

No association with hypertension of CLCNKB and TNFRSF1B polymorphisms at a hypertension locus on chromosome 1p36

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Inactivation of muscle chloride channel by transposon insertion in myotonic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Cloning and functional expression of rat CLC-5, a chloride channel related to kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mutations in the CLCN2 gene are a rare cause of idiopathic generalized epilepsy syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A chloride channel widely expressed in epithelial and non-epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Tonische Krämpfe in willkürlich beweglichen Muskeln in Folge von ererbter psychischer Disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Gating competence of constitutively open CLC-0 mutants revealed by the interaction with a small organic Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Proton sensing of CLC-0 mutant E166D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Cytoplasmic ATP inhibition of CLC-1 is enhanced by low pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

A gene from the Xp22.3 region shares homology with voltage-gated chloride channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Autosomal dominant osteopetrosis: clinical severity and natural history of 94 subjects with a chloride channel 7 gene mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Chloride channel 7 (ClCN7) gene mutations and autosomal dominant osteopetrosis, type II

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Barttin increases surface expression and changes current properties of ClC-K channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Functional and structural analysis of ClC-K chloride channels involved in renal disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

ClC-5: role in endocytosis in the proximal tubule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Pores Formed by Single Subunits in Mixed Dimers of Different CLC Chloride Channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Human ClC-3 is not the swelling-activated chloride channel involved in cell volume regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Modeling study of human renal chloride channel (hCLC-5) mutations suggests a structural-functional relationship.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Functional complementation of truncated human skeletal-muscle chloride channel (hClC-1) using carboxyl tail fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Altered properties of volume-sensitive osmolyte and anion channels (VSOACs) and membrane protein expression in cardiac and smooth muscle myocytes from Clcn3-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Removal of gating in voltage-dependent ClC-2 chloride channel by point mutations affecting the pore and C-terminus CBS-2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Determinants of anion-proton coupling in mammalian endosomal CLC proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Roles of K149, G352, and H401 in the channel functions of ClC-0: testing the predictions from theoretical calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The voltage-dependent ClC-2 chloride channel has a dual gating mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Electron microscopic findings in skin biopsies from patients with infantile osteopetrosis and neuronal storage disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Linkage and mutational analysis of CLCN2 in childhood absence epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Identification and functional characterization of ClC-2 chloride channels in trabecular meshwork cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

The nitrate/proton antiporter AtCLCa mediates nitrate accumulation in plant vacuoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

Involvement of tumor necrosis factor α, rather than interleukin-1α/β or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10409230701829110

10.1080/10409230701829110

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18307107%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference