A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF (Q57184035)

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16 January 2020

title

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF (English)

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16 January 2020

0 references

1

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16 January 2020

Josef Penninger

5

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16 January 2020

Elias Eliopoulos

6

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16 January 2020

Giorgos Kollias

8

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7

Georg Schett

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16 January 2020

author name string

Vagelis Rinotas

2

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Eleni Makrinou

3

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16 January 2020

Jochen Zwerina

4

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publication date

7 November 2011

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16 January 2020

published in

Human Molecular Genetics

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16 January 2020

volume

21

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issue

4

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page(s)

784-798

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Reaching a genetic and molecular understanding of skeletal development

16 January 2020

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Osteoclast differentiation and activation

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TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.

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A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

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TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

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Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity

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Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

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Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

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Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

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RANK is essential for osteoclast and lymph node development

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RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

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RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

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Central control of fever and female body temperature by RANKL/RANK

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Regulation of cancer cell migration and bone metastasis by RANKL.

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Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

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RANK(L) as a key target for controlling bone loss

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Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.

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Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand

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Mutations within the TNF-like core domain of RANKL impair osteoclast differentiation and activation

21 January 2018

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The affinity of human RANK binding to its ligand RANKL.

21 January 2018

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Small-molecule inhibition of TNF-alpha

21 January 2018

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Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis

21 January 2018

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Mixed metastatic lung cancer lesions in bone are inhibited by noggin overexpression and Rank:Fc administration

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A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

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Identifiers

DOI

10.1093/HMG/DDR510

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22068587%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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