Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans (Q57316400)

1

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Nathalie Boucher

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Christian-Marc Lanouette

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Gregor Brookhart

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Anthony G. Comuzzie

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Yvon C. Chagnon

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Roger D. Cone

American Journal of Medical Genetics

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language of work or name

English

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publication date

4 February 2004

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published in

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volume

126A

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issue

3

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page(s)

267-271

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cites work

A polymorphism in the human agouti-related protein is associated with late-onset obesity

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The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice

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The gene structure and minimal promoter of the human agouti related protein

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Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation.

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A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

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Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat

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Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin.

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Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

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Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice

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Modeling the pathways of energy balance using the N1E-115 murine neuroblastoma cell line

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

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Association between an agouti-related protein gene polymorphism and anorexia nervosa

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

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