A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice (Q57369925)

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English	A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice	No description defined

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scholarly article

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A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice (English)

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author name string

Boaz Weisz

1

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Klaudia Giehl

2

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Mali Gana-Weisz

3

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Yaakov Egozi

4

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Gilad Ben-Baruch

5

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Daniela Marciano

6

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Peter Gierschik

7

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Yoel Kloog

8

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language of work or name

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publication date

April 1999

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18

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16

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2579-2588

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1202602

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Stringent structural requirements for anti-Ras activity of S-prenyl analogues

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

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Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer

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Proteins regulating Ras and its relatives

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p21ras: An oncoprotein functioning in growth factor-induced signal transduction

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p21ras is modified by a farnesyl isoprenoid

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How MAP kinases are regulated

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Protein prenylation: more than just glue?

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Human Cancer Syndromes: Clues to the Origin and Nature of Cancer

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Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF.

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The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation

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The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

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Dislodgment and accelerated degradation of Ras.

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Rho GTPases and the actin cytoskeleton

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All ras proteins are polyisoprenylated but only some are palmitoylated

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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

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Reduction of caveolin and caveolae in oncogenically transformed cells

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Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer

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The chemotactic response to PDGF-BB: evidence of a role for Ras.

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The epidermal growth factor receptor in human pancreatic cancer

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Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

1 reference

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Function and regulation of ras.

1 reference

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Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth

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Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

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Signal transduction. How receptors turn Ras on.

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Therapeutic intervention and signaling

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

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Epidermal growth factor-related peptides and their receptors in human malignancies

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation

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Evidence for a high affinity, saturable, prenylation-dependent p21Ha-ras binding site in plasma membranes

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Functional rafts in cell membranes

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Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle

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Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains

1 reference

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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Ras-like GTPases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Epidermal growth factor and its receptors in human pancreatic carcinoma

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202602

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein tyrosine kinases and cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1 reference

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based on heuristic

inferred from DOI database lookup

Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Unexpectedly strong binding of a large metal ion (Bi3+) to human serum transferrin

1 reference

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Ras signaling in tumor necrosis factor-induced apoptosis.

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1202602

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