θ-Defensins Prevent HIV-1 Env-mediated Fusion by Binding gp41 and Blocking 6-Helix Bundle Formation (Q57372497)

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20 January 2020

title

Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation (English)

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1

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Norelle L Daly

9

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David Craik

10

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11

Shibo Jiang

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13

Robert Blumenthal

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20 January 2020

author name string

Wei Wang

2

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20 January 2020

Grace Jung

4

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20 January 2020

Hong Lu

7

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20 January 2020

Xuxia Yan

8

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20 January 2020

Satinder S Rawat

3

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20 January 2020

Alan J Waring

5

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20 January 2020

Alexander M Cole

6

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20 January 2020

Robert I Lehrer

12

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language of work or name

English

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publication date

28 April 2006

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Journal of Biological Chemistry

20 January 2020

published in

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volume

281

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issue

27

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page(s)

18787-18792

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20 January 2020

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https://api.crossref.org/works/10.1074%2FJBC.M602422200

Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins

21 January 2018

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A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins

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Evolution of primate theta-defensins: a serpentine path to a sweet tooth

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Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1.

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RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates.

21 January 2018

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A theta-defensin composed exclusively of D-amino acids is active against HIV-1.

21 January 2018

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Activity of alpha- and theta-defensins against primary isolates of HIV-1

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Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry

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Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins

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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

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Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

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1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Atomic structure of the ectodomain from HIV-1 gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Core structure of gp41 from the HIV envelope glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Atomic structure of a thermostable subdomain of HIV-1 gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M602422200

A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition

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https://api.crossref.org/works/10.1074%2FJBC.M602422200

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Design and properties of N(CCG)-gp41, a chimeric gp41 molecule with nanomolar HIV fusion inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Protein design of an HIV-1 entry inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41.

21 January 2018

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Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Capture of an early fusion-active conformation of HIV-1 gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

The HIV Env-mediated fusion reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

The θ-Defensin, Retrocyclin, Inhibits HIV-1 Entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Retrocyclin, an Antiretroviral θ-Defensin, Is a Lectin

21 January 2018

1 reference

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Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion

21 January 2018

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CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4.

21 January 2018

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Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein

21 January 2018

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Functional expression of CD4, CXCR4, and CCR5 in glycosphingolipid-deficient mouse melanoma GM95 cells and susceptibility to HIV-1 envelope glycoprotein-triggered membrane fusion

21 January 2018

1 reference

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Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

21 January 2018

1 reference

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Conformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Temperature-dependent intermediates in HIV-1 envelope glycoprotein-mediated fusion revealed by inhibitors that target N- and C-terminal helical regions of HIV-1 gp41.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M602422200

Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region

21 January 2018

1 reference

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HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M602422200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16648135%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference