Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin (Q57397536)

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scientific article published on 15 November 2003

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English	Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin	scientific article published on 15 November 2003

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scholarly article

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21 December 2019

Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin (English)

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21 December 2019

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Consolato Sergi

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21 December 2019

Matthias Hentze

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Wolfgang Stremmel

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21 December 2019

Thomas Herrmann

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Thomas Herrmann

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21 December 2019

Martina U Muckenthaler

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Martina Muckenthaler

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Frank van der Hoeven

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Karen Brennan

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21 December 2019

Nadia Hubert

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21 December 2019

Hermann-Josef Gröne

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21 December 2019

Iris Kaiser

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21 December 2019

Isabella Gosch

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21 December 2019

Martin Volkmann

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21 December 2019

Hans-Dieter Riedel

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21 December 2019

Sven G Gehrke

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21 December 2019

A Francis Stewart

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publication date

15 November 2003

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21 December 2019

Journal of Molecular Medicine

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21 December 2019

82

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21 December 2019

39-48

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21 December 2019

1

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21 December 2019

https://scigraph.springernature.com/pub.10.1007/s00109-003-0508-x

0 references

Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HFE, the MHC and hemochromatosis: Paradigm for an extended function for MHC class I

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mouse HFE gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal expression of genes involved in iron absorption in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of iron absorption in Hfe mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new logic for DNA engineering using recombination in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A duodenal mucosal abnormality in the reduction of Fe(III) in patients with genetic haemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C282Y mutation causing hereditary hemochromatosis does not produce a null allele

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA cloning by homologous recombination in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron release from human monocytes after erythrophagocytosis in vitro: an investigation in normal subjects and hereditary hemochromatosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transferrin receptor binding site on HFE, the class I MHC-related protein mutated in hereditary hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An iron-regulated ferric reductase associated with the absorption of dietary iron

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absorption of iron; radioiron studies in idiopathic hemochromatosis, malnutritional cytosiderosis, and transfusional hemosiderosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simplified generation of targeting constructs using ET recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic failure with neonatal tissue siderosis of hemochromatotic type in an infant presenting with meconium ileus. Case report and differential diagnosis of the perinatal iron storage disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duodenal mucosal reductase in wild-type and Hfe knockout mice on iron adequate, iron deficient, and iron rich feeding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased liver hepcidin expression in the Hfe knockout mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of the ectodomain of HFE with the transferrin receptor are critical for iron homeostasis in cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hemochromatosis protein HFE inhibits iron export from macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HFE gene knockout produces mouse model of hereditary hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/14618243

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00109-003-0508-X

1 reference

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21 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14618243%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

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