Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test (Q57402000)

From Wikidata

Jump to navigation Jump to search

scientific article published on 19 October 2010

Language	Label	Description	Also known as
English	Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test	scientific article published on 19 October 2010

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

0 references

Anette P. Gjesing

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Allan Linneberg

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Carolyn F. Deacon

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Jens Juul Holst

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Oluf Borbye Pedersen

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

author name string

L L Kjems

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

M A Vestmar

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

publication date

19 October 2010

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

54

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

103-110

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentin

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1940-4

21 January 2018

Proglucagon-derived peptides: mechanisms of action and therapeutic potential

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1940-4

21 January 2018

Unraveling the science of incretin biology.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-010-1940-4

21 January 2018

Islet specific Wnt activation in human type II diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translating TCF7L2: from gene to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preliminary report: No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ISEC: a program to calculate insulin secretion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, measurement, and secretion of human glucagon-like peptide-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT/beta-catenin increases the production of incretins by entero-endocrine cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific alternative splicing of TCF7L2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measuring pre-hepatic insulin secretion using a population model of C-peptide kinetics: accuracy and required sampling schedule.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in development and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20957343

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-010-1940-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20957343%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q57402000&oldid=2213452627"