Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? (Q37173779)

18 August 2017

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title

Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? (English)

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18 August 2017

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J C Florez

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18 August 2017

27 May 2008

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18 August 2017

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18 August 2017

51

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18 August 2017

7

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18 August 2017

1100-1110

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https://scigraph.springernature.com/pub.10.1007/s00125-008-1025-9

18 August 2017

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A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

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Insulin resistance is not necessarily an essential component of type 2 diabetes

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E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

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Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro

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The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits

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A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

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Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

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Immunoassay of endogenous plasma insulin in man

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Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.

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Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

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Genome-wide association studies provide new insights into type 2 diabetes aetiology

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The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

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ENPP1 gene, insulin resistance and related clinical outcomes

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Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function

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K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

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Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population

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Genetic prediction of future type 2 diabetes

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

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Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes

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Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans

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Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

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ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

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Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM.

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Nonketotic diabetes mellitus: insulin deficiency or insulin resistance?

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Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort

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TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

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Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns

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Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects.

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Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis.

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Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

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12 December 2020

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

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The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects

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TCF7L2: the biggest story in diabetes genetics since HLA?

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12 December 2020

Common variants in HNF-1 alpha and risk of type 2 diabetes

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Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes

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12 December 2020

Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM

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12 December 2020

Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans.

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12 December 2020

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

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12 December 2020

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations

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12 December 2020

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals

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12 December 2020

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

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12 December 2020

Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

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12 December 2020

Genetic basis of maturity-onset diabetes of the young

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12 December 2020

A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

1 reference

12 December 2020

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

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12 December 2020

Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative.

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12 December 2020

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

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12 December 2020

Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals.

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12 December 2020

A genome-wide association study identifies novel risk loci for type 2 diabetes

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12 December 2020

Common Variants of the Hepatocyte Nuclear Factor-4 P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

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12 December 2020

Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population

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12 December 2020

Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone

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12 December 2020

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses

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12 December 2020

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.

1 reference

12 December 2020

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

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12 December 2020

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

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12 December 2020

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

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12 December 2020

A Large-Scale Association Analysis of Common Variation of the HNF1 Gene With Type 2 Diabetes in the U.K. Caucasian Population

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12 December 2020

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program

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12 December 2020

Molecular biology of adenosine triphosphate-sensitive potassium channels

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12 December 2020

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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12 December 2020

Diabetes mellitus and genetically programmed defects in beta-cell function

1 reference

12 December 2020

Saturated and cis/trans unsaturated acyl CoA esters differentially regulate wild-type and polymorphic beta-cell ATP-sensitive K+ channels

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12 December 2020

Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

1 reference

12 December 2020

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

1 reference

12 December 2020

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population

1 reference

12 December 2020

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

1 reference

12 December 2020

The new type 2 diabetes gene TCF7L2

1 reference

12 December 2020

Common variants in WFS1 confer risk of type 2 diabetes

1 reference

12 December 2020

Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium

1 reference

12 December 2020

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

1 reference

12 December 2020

Clinical and molecular genetic analysis of 19 Wolfram syndrome kindreds demonstrating a wide spectrum of mutations in WFS1

1 reference

12 December 2020

Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses

1 reference

12 December 2020

Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people

1 reference

12 December 2020

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study

1 reference

12 December 2020

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

12 December 2020

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

1 reference

12 December 2020

Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies

1 reference

12 December 2020

10.1007/S00125-008-1025-9

Identifiers

DOI

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18 August 2017

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PubMed ID

18504548