Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cells (Q57635926)

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3 January 2020

title

Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cells (English)

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3 January 2020

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3

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author name string

Kyu-Tae Kim

1

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3 January 2020

Kristin Baird

2

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3 January 2020

Obdulio Piloto

4

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3 January 2020

Mark Levis

5

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3 January 2020

Li Li

6

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3 January 2020

Peili Chen

7

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Paul Meltzer

8

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Donald Small

9

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language of work or name

English

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publication date

1 September 2007

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British Journal of Haematology

3 January 2020

published in

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3 January 2020

volume

138

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issue

5

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page(s)

603-615

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Adult Burkitt leukemia and lymphoma

3 January 2020

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Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl

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Use of a cDNA microarray to analyse gene expression patterns in human cancer

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Delineation of prognostic biomarkers in prostate cancer

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Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

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The roles of FLT3 in hematopoiesis and leukemia

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain

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CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).

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Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival

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FLT3: ITDoes matter in leukemia

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A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

21 January 2018

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A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

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In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects

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Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

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Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways

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Gene expression profiling of pediatric acute myelogenous leukemia

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The role of FLT3 in haematopoietic malignancies

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Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation.

21 January 2018

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Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor

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Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor

21 January 2018

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Prognostically useful gene-expression profiles in acute myeloid leukemia.

21 January 2018

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Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

21 January 2018

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

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SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase

21 January 2018

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Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

21 January 2018

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FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells

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21 January 2018

Identifiers

DOI

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3 January 2020

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