Intraneuronal -Amyloid Expression Downregulates the Akt Survival Pathway and Blunts the Stress Response (Q57777652)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

12 May 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

12 May 2020

Gunnar K. Gouras

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

12 May 2020

author name string

Kenneth M Rosen

2

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12 May 2020

Roy C Smith

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

12 May 2020

Kenneth Walsh

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

12 May 2020

Henry W Querfurth

6

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12 May 2020

language of work or name

English

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publication date

23 November 2005

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published in

Journal of Neuroscience

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12 May 2020

volume

25

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12 May 2020

issue

47

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12 May 2020

page(s)

10960-10969

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

12 May 2020

cites work

1 reference

12 December 2020

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

12 December 2020

Direct observation of stress response in Caenorhabditis elegans using a reporter transgene

1 reference

12 December 2020

Intraneuronal Abeta42 accumulation in human brain.

1 reference

12 December 2020

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

12 December 2020

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

1 reference

12 December 2020

Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.

1 reference

12 December 2020

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

1 reference

12 December 2020

Apoptosis in the nervous system

1 reference

12 December 2020

Opposing actions of phosphatidylinositol 3-kinase and glycogen synthase kinase-3beta in the regulation of HSF-1 activity

1 reference

12 December 2020

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

1 reference

12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

12 December 2020

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

1 reference

12 December 2020

Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy

1 reference

12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

12 December 2020

Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2.

1 reference

12 December 2020

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

1 reference

12 December 2020

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

1 reference

12 December 2020

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

1 reference

12 December 2020

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

1 reference

12 December 2020

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

1 reference

12 December 2020

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

12 December 2020

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

1 reference

12 December 2020

Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo

1 reference

12 December 2020

Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region

1 reference

12 December 2020

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

12 December 2020

Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.

1 reference

12 December 2020

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.

1 reference

12 December 2020

RNAi functions in cultured mammalian neurons

1 reference

12 December 2020

Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling.

1 reference

12 December 2020

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

12 December 2020

PKB binding proteins. Getting in on the Akt.

1 reference

12 December 2020

Late Simian virus 40 transcription factor is a target of the phosphoinositide 3-kinase/Akt pathway in anti-apoptotic Alzheimer's amyloid precursor protein signalling

1 reference

12 December 2020

Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model

1 reference

12 December 2020

Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism

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12 December 2020

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions

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12 December 2020

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

1 reference

12 December 2020

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

1 reference

12 December 2020

Control of synaptic strength, a novel function of Akt.

1 reference

12 December 2020

High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

1 reference

12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

12 December 2020

Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

1 reference

12 December 2020

p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

1 reference

12 December 2020

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

1 reference

12 December 2020

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

1 reference

12 December 2020

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

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12 December 2020

In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment

1 reference

12 December 2020

Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations

1 reference

12 December 2020

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

1 reference

12 December 2020

Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival

1 reference

12 December 2020

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

1 reference

12 December 2020

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease

1 reference

12 December 2020

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

1 reference

12 December 2020

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

1 reference

12 December 2020

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

1 reference

12 December 2020

Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

1 reference

12 December 2020

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

1 reference

12 December 2020

A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

1 reference

12 December 2020

Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.

1 reference

12 December 2020

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease

1 reference

12 December 2020

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

1 reference

12 December 2020

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

12 December 2020

Akt/FOXO3a signaling modulates the endothelial stress response through regulation of heat shock protein 70 expression

1 reference

12 December 2020

Amyloid beta-peptide: the inside story

1 reference

12 December 2020

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

12 December 2020

Methods for construction of adenovirus vectors

1 reference

12 December 2020

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

1 reference

12 December 2020

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

12 December 2020

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

12 December 2020

Nuclear and cytoplasmic localization of the beta-amyloid peptide (1-43) in transfected 293 cells

1 reference

12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

12 December 2020

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice

1 reference

12 December 2020

Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1

1 reference

12 December 2020

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

12 December 2020

beta-catenin is a target for the ubiquitin-proteasome pathway

1 reference

12 December 2020

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

1 reference

12 December 2020

Phosphatidylinositol 3-kinase: increased activity and protein level in amyotrophic lateral sclerosis.

1 reference

12 December 2020

Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis

1 reference

12 December 2020

10.1523/JNEUROSCI.1723-05.2005

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725865&resulttype=core&format=json

12 May 2020

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