A Kinetic Mechanism for the Polymerization of α1-Antitrypsin (Q57980265)

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12 November 2019

title

A kinetic mechanism for the polymerization of alpha1-antitrypsin (English)

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12 November 2019

1

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12 November 2019

author name string

R Mahadeva

2

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12 November 2019

P R Elliott

3

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12 November 2019

P Sivasothy

4

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12 November 2019

D A Lomas

5

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12 November 2019

language of work or name

English

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publication date

1 April 1999

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Journal of Biological Chemistry

12 November 2019

published in

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12 November 2019

volume

274

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12 November 2019

page(s)

9548-9555

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12 November 2019

issue

14

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Human plasma proteinase inhibitors

12 November 2019

cites work

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Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

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Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins

21 January 2018

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Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution

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The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

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Synthesis of pppGpN typs dinucleotide derivatives: the 5′ end sequence of some RNAs

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Structural basis of latency in plasminogen activator inhibitor-1

21 January 2018

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Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

21 January 2018

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The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved alpha1-antitrypsin at 2.7 A

21 January 2018

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Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

21 January 2018

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Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

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Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis

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Latent alpha1-antichymotrypsin. A molecular explanation for the inactivation of alpha1-antichymotrypsin in chronic bronchitis and emphysema.

21 January 2018

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The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

21 January 2018

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The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

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alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.

21 January 2018

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Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)

21 January 2018

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Antithrombin-TRI (Ala382 to Thr) causing severe thromboembolic tendency undergoes the S-to-R transition and is associated with a plasma-inactive high-molecular-weight complex of aggregated antithrombin.

21 January 2018

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COOH-terminal substitutions in the serpin C1 inhibitor that cause loop overinsertion and subsequent multimerization

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The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

21 January 2018

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Serpin alpha 1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy

21 January 2018

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Effects of mutations in the hinge region of serpins

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21 January 2018

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What do dysfunctional serpins tell us about molecular mobility and disease?

21 January 2018

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Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins

21 January 2018

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Amyloid fibril formation and protein misassembly: a structural quest for insights into amyloid and prion diseases

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Alternative conformations of amyloidogenic proteins govern their behavior

21 January 2018

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Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity

21 January 2018

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Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease

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21 January 2018

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Preparation and characterization of latent alpha 1-antitrypsin

21 January 2018

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Crystallization, activity assay and preliminary X-ray diffraction analysis of the uncleaved form of the serpin antichymotrypsin

21 January 2018

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Probing the native strain iin alpha1-antitrypsin

21 January 2018

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Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

21 January 2018

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Structural explanation for the deficiency of S alpha 1-antitrypsin

21 January 2018

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Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis

21 January 2018

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Folding pathway of human alpha 1-antitrypsin: characterization of an intermediate that is active but prone to aggregation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.274.14.9548

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10092640%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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