The application of thermodynamic methods in drug design (Q58023127)

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Thermodynamic Basis of Resistance to HIV-1 Protease Inhibition: Calorimetric Analysis of the V82F/I84V Active Site Resistant Mutant†

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Resistance to HIV protease inhibitors: a comparison of enzyme inhibition and antiviral potency.

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

The effect of inhibitor binding on the structural stability and cooperativity of the HIV-1 protease.

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity.

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

The enthalpy change in protein folding and binding: refinement of parameters for structure-based calculations.

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Evaluation of linked protonation effects in protein binding reactions using isothermal titration calorimetry

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Protein Structure and the Energetics of Protein Stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0040-6031%2801%2900671-2

7 January 2021