Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice (Q58045882)

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title

Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice (English)

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Steven P Wilder

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Richard H Barton

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Mark McCarthy

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Roger Tatoud

14

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Jeremy K. Nicholson

15

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Dominique Gauguier

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author name string

A A Toye

1

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C Blancher

3

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A R Rothwell

4

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J F Fearnside

5

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M T Bihoreau

7

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O Cloarec

8

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I Azzouzi

9

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S Young

10

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J Scott

16

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E Holmes

12

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publication date

6 July 2007

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volume

50

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issue

9

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page(s)

1867-1879

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https://scigraph.springernature.com/pub.10.1007/s00125-007-0738-5

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exact match

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Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

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Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

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Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

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New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

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Molecular mediators of hepatic steatosis and liver injury

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LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1

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Transcriptional regulation of metabolism

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Transcript profiling suggests that differential metabolic adaptation of mice to a high fat diet is associated with changes in liver to muscle lipid fluxes

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10.1007/S00125-007-0738-5

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DOI

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1 January 2020

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