Signalling mechanisms linking hepatic glucose and lipid metabolism (Q36485655)

14 August 2017

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title

Signalling mechanisms linking hepatic glucose and lipid metabolism (English)

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14 August 2017

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M O Weickert

1

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PubMed ID

16718463

14 August 2017

A F H Pfeiffer

series ordinal

2

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14 August 2017

23 May 2006

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14 August 2017

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14 August 2017

49

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14 August 2017

1732-1741

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14 August 2017

8

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https://scigraph.springernature.com/pub.10.1007/s00125-006-0295-3

14 August 2017

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cites work

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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https://api.crossref.org/works/10.1007%2FS00125-006-0295-3

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-006-0295-3

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-006-0295-3

Novel concepts in insulin regulation of hepatic gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0295-3

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0295-3

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

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12 December 2020

Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

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12 December 2020

Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome

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12 December 2020

Adiponectin and protection against type 2 diabetes mellitus

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12 December 2020

AMP-activated protein kinase: balancing the scales.

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12 December 2020

Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity

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12 December 2020

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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12 December 2020

Intracellular regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase (11beta-HSD)-1 plays a key role in regulation of the hypothalamic-pituitary-adrenal axis: analysis of 11beta-HSD-1-deficient mice

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12 December 2020

Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.

1 reference

12 December 2020

Role of stearoyl-coenzyme A desaturase in lipid metabolism

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12 December 2020

Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes

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12 December 2020

Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

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12 December 2020

PPAR Tissue Distribution and Interactions with Other Hormone-Signaling Pathways

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12 December 2020

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

1 reference

12 December 2020

Insulin-regulated gene expression

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12 December 2020

Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients.

1 reference

12 December 2020

Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years.

1 reference

12 December 2020

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

1 reference

12 December 2020

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

1 reference

12 December 2020

Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system

1 reference

12 December 2020

Roles of PPARs in health and disease.

1 reference

12 December 2020

Does central obesity reflect "Cushing's disease of the omentum"?

1 reference

12 December 2020

Hepatic glucose metabolism in humans--its role in health and disease

1 reference

12 December 2020

Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver

1 reference

12 December 2020

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

1 reference

12 December 2020

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

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12 December 2020

Transcriptional repression of atherogenic inflammation: modulation by PPARdelta

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12 December 2020

Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice

1 reference

12 December 2020

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

1 reference

12 December 2020

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

1 reference

12 December 2020

Nonalcoholic fatty liver disease

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12 December 2020

Hepatocarcinogenesis of peroxisome proliferators

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12 December 2020

Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes

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12 December 2020

Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.

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12 December 2020

Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid beta-oxidation

1 reference

12 December 2020

Malonyl-CoA, fuel sensing, and insulin resistance

1 reference

12 December 2020

A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis

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12 December 2020

Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers

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12 December 2020

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

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12 December 2020

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

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12 December 2020

Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes

1 reference

12 December 2020

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1 reference

12 December 2020

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

1 reference

12 December 2020

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

1 reference

12 December 2020

Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis

1 reference

12 December 2020

Fatty acid regulation of hepatic gene transcription.

1 reference

12 December 2020

Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice

1 reference

12 December 2020

The Endocrine Effects of Long-Term Treatment with Mifepristone (RU 486)

1 reference

12 December 2020

Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta

1 reference

12 December 2020

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue

1 reference

12 December 2020

Regulation of glucose production by the liver

1 reference

12 December 2020

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase

1 reference

12 December 2020

Insulin acutely decreases hepatic fatty acid synthase activity

1 reference

12 December 2020

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

1 reference

12 December 2020

Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha

1 reference

12 December 2020

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids

1 reference

12 December 2020

Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice

1 reference

12 December 2020

Glucose and insulin function through two distinct transcription factors to stimulate expression of lipogenic enzyme genes in liver.

1 reference

12 December 2020

Rosiglitazone in the treatment of HAART-associated lipodystrophy--a randomized double-blind placebo-controlled study.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

1 reference

12 December 2020

A brain-liver circuit regulates glucose homeostasis

1 reference

12 December 2020

A high-cholesterol, n-3 polyunsaturated fatty acid diet causes different responses in rats and hamsters.

1 reference

12 December 2020

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

1 reference

12 December 2020

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

12 December 2020

Re-emergence of fibrates in the management of dyslipidemia and cardiovascular risk

1 reference

12 December 2020

Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue.

1 reference

12 December 2020

Old fat, make way for new fat.

1 reference

12 December 2020

Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles

1 reference

12 December 2020

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

1 reference

12 December 2020

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

1 reference

12 December 2020

Therapeutic roles of peroxisome proliferator-activated receptor agonists

1 reference

12 December 2020

Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

1 reference

12 December 2020

Management of cellular energy by the AMP-activated protein kinase system

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12 December 2020

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription

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12 December 2020

Putative metabolic effects of the liver X receptor (LXR).

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12 December 2020

Glucose regulation of gene transcription

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12 December 2020

Effects of free fatty acids on gluconeogenesis and glycogenolysis

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12 December 2020

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

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12 December 2020

Pharmacotherapy for dyslipidaemia – current therapies and future agents

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12 December 2020

Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes

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12 December 2020

Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

1 reference

12 December 2020

Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells.

1 reference

12 December 2020

The orphan nuclear hormone receptor LXR alpha interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling

1 reference

12 December 2020

Synergistic induction of apoptosis with glucocorticoids and 3',5'-cyclic adenosine monophosphate reveals agonist activity by RU 486.

1 reference

12 December 2020

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

1 reference

12 December 2020

SREBPs suppress IRS-2-mediated insulin signalling in the liver.

1 reference

12 December 2020

Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms

1 reference

12 December 2020

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

1 reference

12 December 2020

Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C

1 reference

12 December 2020

PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.

1 reference

12 December 2020

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

1 reference

12 December 2020

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

1 reference

12 December 2020

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

1 reference

12 December 2020

The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression

1 reference

12 December 2020

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion

1 reference

12 December 2020

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

1 reference

12 December 2020

Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase

1 reference

12 December 2020

Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage

1 reference

12 December 2020

Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes

1 reference

12 December 2020

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

1 reference

12 December 2020

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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12 December 2020

Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

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12 December 2020

Molecular mediators of hepatic steatosis and liver injury

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12 December 2020

The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

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12 December 2020

LXRs regulate the balance between fat storage and oxidation.

1 reference

12 December 2020

Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio

1 reference

12 December 2020

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

1 reference

12 December 2020

Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study

1 reference

12 December 2020

Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo

1 reference

12 December 2020

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

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12 December 2020

Regulation of blood glucose by hypothalamic pyruvate metabolism

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12 December 2020

10.1007/S00125-006-0295-3

Identifiers

DOI

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14 August 2017

1 reference

PubMed ID

16718463