TSC1–TSC2: a complex tale of PKB-mediated S6K regulation (Q58438038)

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12 November 2019

title

TSC1-TSC2: a complex tale of PKB-mediated S6K regulation (English)

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12 November 2019

2

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12 November 2019

author name string

Edward J McManus

series ordinal

1

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12 November 2019

publication date

1 September 2002

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12 November 2019

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12 November 2019

volume

4

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12 November 2019

issue

9

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12 November 2019

page(s)

E214-6

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https://scigraph.springernature.com/pub.10.1038/ncb0902-e214

12 November 2019

exact match

0 references

cites work

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Morphogenetic mutants detected in mitotic recombination clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Akt regulates growth by directly phosphorylating Tsc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCB0902-E214

21 January 2018

Identifiers

DOI

10.1038/NCB0902-E214

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12205484%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference