RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner (Q58611356)

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English	RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner	article

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1 May 2020

RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner (English)

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1 May 2020

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Yusuke Marikawa

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1 May 2020

Vernadeth B Alarcon

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1 May 2020

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1 February 2019

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1 May 2020

Molecular Human Reproduction

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1 May 2020

25

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1 May 2020

2

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1 May 2020

43-60

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1 May 2020

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Sodium-dependent amino acid transport in preimplantation mouse embryos. III. Na+-k+-atpase-linked mechanism in blastocysts

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Immunosurgery of mouse blastocyst

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Genetic control of extraembryonic cell lineages studied with tetraploid<-->diploid chimeric concepti

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Recognition of RhoA by Clostridium botulinum C3 exoenzyme

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on folding of its N-terminal domain.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Multipotent cell lineages in early mouse development depend on SOX2 function

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Molecular study of mouse peri-implantation development using the in vitro culture of aggregated inner cell mass

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Downregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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TEAD mediates YAP-dependent gene induction and growth control

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Blastomeres of the mouse embryo lose totipotency after the fifth cleavage division: expression of Cdx2 and Oct4 and developmental potential of inner and outer blastomeres of 16- and 32-cell embryos.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Individual blastomeres of 16- and 32-cell mouse embryos are able to develop into foetuses and mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Hippo pathway regulation by cell morphology and stress fibers.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Generation and live imaging of an endogenous Cdx2 reporter mouse line

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Creation of trophectoderm, the first epithelium, in mouse preimplantation development

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Maternal Cdx2 is dispensable for mouse development

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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The Hippo pathway member Nf2 is required for inner cell mass specification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Angiomotin prevents pluripotent lineage differentiation in mouse embryos via Hippo pathway-dependent and -independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological roles of Rho and Rho effectors in mammals

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Angiomotins link F-actin architecture to Hippo pathway signaling

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Organization and execution of the epithelial polarity programme

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Metabolic control of YAP and TAZ by the mevalonate pathway.

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Initiation of Hippo signaling is linked to polarity rather than to cell position in the pre-implantation mouse embryo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Towards understanding the roles of position and geometry on cell fate decisions during preimplantation development

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-modifying bacterial protein toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of Hippo pathway regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Tead and AP1 Coordinate Transcription and Motility.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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Optimizing the culture environment and embryo manipulation to help maintain embryo developmental potential

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Statins inhibit blastocyst formation by preventing geranylgeranylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Regulating Rho GTPases and their regulators

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https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho-associated protein kinase regulates subcellular localisation of Angiomotin and Hippo-signalling during preimplantation mouse embryo development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric division of contractile domains couples cell positioning and fate specification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Characterization of Hippo Pathway Components by Gene Inactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

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The enigma of embryonic diapause

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Regulation of Hippo Signaling by Actin Remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Spatiotemporal Regulation of RhoA during Cytokinesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Rho signaling research: history, current status and future directions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Chromosomal analysis in IVF: just how useful is it?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30395288

12 December 2020

based on heuristic

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Identifiers

10.1093/MOLEHR/GAY048

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30395288%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30395288%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30395288%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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