Emerging pharmacotherapies for diabetic macular edema (Q58907881)

Experimental Diabetes Research

17 June 2019

diabetic macular edema

1 reference

3

Harry W Flynn

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author name string

Golnaz Javey

series ordinal

1

0 references

Stephen G Schwartz

series ordinal

2

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language of work or name

English

0 references

publication date

26 February 2012

6 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

17 June 2019

7 January 2023

6 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

17 June 2019

7 January 2023

2012

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page(s)

548732

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copyright license

Creative Commons Attribution 3.0 Unported

6 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

17 June 2019

on focus list of Wikimedia project

7 January 2023

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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The DA VINCI Study: phase 2 primary results of VEGF Trap-Eye in patients with diabetic macular edema

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A phase 2/3, multicenter, randomized, double-masked, 2-year trial of pegaptanib sodium for the treatment of diabetic macular edema

30 November 2018

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Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients

30 November 2018

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Long-term benefit of sustained-delivery fluocinolone acetonide vitreous inserts for diabetic macular edema.

30 November 2018

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The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema.

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Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

30 November 2018

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Randomized trial evaluating short-term effects of intravitreal ranibizumab or triamcinolone acetonide on macular edema after focal/grid laser for diabetic macular edema in eyes also receiving panretinal photocoagulation

30 November 2018

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Significance of outer blood-retina barrier breakdown in diabetes and ischemia

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Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE Study): a 12-month, randomized, controlled, double-masked, multicenter phase II study

30 November 2018

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Factors associated with visual acuity outcomes after vitrectomy for diabetic macular edema: diabetic retinopathy clinical research network

30 November 2018

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Two-year outcomes of the ranibizumab for edema of the mAcula in diabetes (READ-2) study

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Sustained elevation of intraocular pressure after intravitreal injections of anti-VEGF agents

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Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1.

30 November 2018

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Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

30 November 2018

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A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2.

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Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study

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Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study

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Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction

30 November 2018

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Diabetic macular oedema: physical, physiological and molecular factors contribute to this pathological process

30 November 2018

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Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Sustained ocular delivery of fluocinolone acetonide by an intravitreal insert

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Topical mecamylamine for diabetic macular edema

30 November 2018

1 reference

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A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy

30 November 2018

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Effects of intravitreal erythropoietin therapy for patients with chronic and progressive diabetic macular edema

30 November 2018

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Preliminary assessment of celecoxib and microdiode pulse laser treatment of diabetic macular edema

30 November 2018

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30 November 2018

Cystoid macular edema

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Intravitreal plasmin without associated vitrectomy as a treatment for refractory diabetic macular edema.

30 November 2018

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Endophthalmitis after intravitreal injections

30 November 2018

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Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema

30 November 2018

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30 November 2018

Enzymatic vitreolysis.

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Intravitreal inserts of steroids to treat diabetic macular edema

30 November 2018

1 reference

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Metabolic control and diabetic retinopathy

30 November 2018

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An exploratory study of the safety, tolerability and bioactivity of a single intravitreal injection of vascular endothelial growth factor Trap-Eye in patients with diabetic macular oedema

30 November 2018

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The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes

30 November 2018

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A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Rosiglitazone and delayed onset of proliferative diabetic retinopathy

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Enzymatic vitreous disruption

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Cystoid and diabetic macular edema treated with nepafenac 0.1%.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.

30 November 2018

1 reference

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The risk of endophthalmitis following intravitreal triamcinolone injection in the DRCRnet and SCORE clinical trials

30 November 2018

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A phase II randomized clinical trial of intravitreal bevacizumab for diabetic macular edema

30 November 2018

1 reference

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The Use of Intravitreal Etanercept in Diabetic Macular Oedema

30 November 2018

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Randomized trial of peribulbar triamcinolone acetonide with and without focal photocoagulation for mild diabetic macular edema: a pilot study

30 November 2018

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Objective evaluation of cataract progression associated with a high dose intravitreal triamcinolone injection.

30 November 2018

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Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

30 November 2018

1 reference

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Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Fenofibrate: a review of its use in primary dyslipidaemia, the metabolic syndrome and type 2 diabetes mellitus

30 November 2018

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Placental growth factor-1 and epithelial haemato-retinal barrier breakdown: potential implication in the pathogenesis of diabetic retinopathy

30 November 2018

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Changes in membrane conductance play a pathogenic role in osmotic glial cell swelling in detached retinas

30 November 2018

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Ranibizumab versus verteporfin for neovascular age-related macular degeneration.

30 November 2018

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Ranibizumab for neovascular age-related macular degeneration

30 November 2018

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Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Role of vascular endothelial growth factor in ocular angiogenesis

30 November 2018

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Diabetic macular edema associated with glitazone use.

30 November 2018

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Single periocular injection of celecoxib-PLGA microparticles inhibits diabetes-induced elevations in retinal PGE2, VEGF, and vascular leakage.

30 November 2018

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Intravitreal injection versus sub-Tenon's infusion of triamcinolone acetonide for refractory diabetic macular edema: a randomized clinical trial

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Pooled efficacy results from two multinational randomized controlled clinical trials of a single intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage.

30 November 2018

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The pathobiology of diabetic complications: a unifying mechanism

30 November 2018

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Presumed sterile endophthalmitis following intravitreal triamcinolone acetonide injection

30 November 2018

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Intravitreal triamcinolone acetonide and intraocular pressure

30 November 2018

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Intrasurgical plasmin enzyme in diabetic macular edema.

30 November 2018

1 reference

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Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412.

30 November 2018

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Protein kinase C inhibition and diabetic retinopathy: a shot in the dark at translational research

30 November 2018

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Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies

30 November 2018

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A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

30 November 2018

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The potential role of PKC beta in diabetic retinopathy and macular edema

30 November 2018

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Diabetic retinopathy: more than meets the eye.

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Macular edema reflects generalized vascular hyperpermeability in type 2 diabetic patients with retinopathy

30 November 2018

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Quantitative assessment of the integrity of the blood-retinal barrier in mice

30 November 2018

1 reference

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Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression

30 November 2018

1 reference

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Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

30 November 2018

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Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation

30 November 2018

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Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy

30 November 2018

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Rosiglitazone taken once daily provides effective glycaemic control in patients with Type 2 diabetes mellitus.

30 November 2018

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

30 November 2018

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Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro.

30 November 2018

1 reference

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Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion

30 November 2018

1 reference

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A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

30 November 2018

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Retinal vessel dilatation and elongation precedes diabetic macular oedema

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids

30 November 2018

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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

30 November 2018

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

30 November 2018

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Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

30 November 2018

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The molecular heterogeneity of protein kinase C and its implications for cellular regulation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299388

Vitrectomy for diabetic macular edema associated with a thickened and taut posterior hyaloid membrane

30 November 2018

1 reference

12 December 2020

High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent

1 reference

12 December 2020

Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab

1 reference

12 December 2020

Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease

1 reference

12 December 2020

1 reference

12 December 2020

Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates

1 reference

12 December 2020

Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor

1 reference

12 December 2020

Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia

1 reference

12 December 2020

Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Early Treatment Diabetic Retinopathy Study research group

1 reference

12 December 2020

The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized cl

1 reference

12 December 2020

Ten-year incidence of diabetic retinopathy and macular edema. Risk factors in a sample of people with type 1 diabetes

1 reference

12 December 2020

Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage

1 reference

12 December 2020

The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema

1 reference

12 December 2020

Mechanisms of hepatocyte growth factor-induced retinal endothelial cell migration and growth

1 reference

12 December 2020

Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study

1 reference

12 December 2020

Fluocinolone acetonide ophthalmic--Bausch & Lomb: fluocinolone acetonide Envision TD implant

1 reference

12 December 2020

Increased vasodilatory prostaglandin production in the diabetic rat retinal vasculature

1 reference

12 December 2020