Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics (Q59006209)

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21 March 2020

title

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics (English)

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2

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Jesper Wengel

series ordinal

3

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21 March 2020

author name string

Sakari Kauppinen

series ordinal

1

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21 March 2020

publication date

1 January 2005

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Drug discovery today. Technologies

21 March 2020

published in

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21 March 2020

volume

2

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page(s)

287-290

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issue

3

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MicroRNA expression in zebrafish embryonic development

21 March 2020

cites work

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12 December 2020

RNA interference in mammalian cells by chemically-modified RNA.

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12 December 2020

A microRNA polycistron as a potential human oncogene

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12 December 2020

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

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12 December 2020

microRNAs: tiny regulators with great potential

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12 December 2020

Direct isolation of poly(A)+ RNA from 4 M guanidine thiocyanate-lysed cell extracts using locked nucleic acid-oligo(T) capture.

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12 December 2020

Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes

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12 December 2020

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

MicroRNA expression profiles classify human cancers

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12 December 2020

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

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12 December 2020

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

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12 December 2020

MicroRNAs: genomics, biogenesis, mechanism, and function

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12 December 2020

LNA-antisense rivals siRNA for gene silencing

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12 December 2020

Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

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12 December 2020

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties

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12 December 2020

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

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12 December 2020

Antisense knockdown of PKC-alpha using LNA-oligos

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12 December 2020

Design of antisense oligonucleotides stabilized by locked nucleic acids

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12 December 2020

Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV-1 genome dimerization and inhibit virus replication.

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12 December 2020

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

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12 December 2020

A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2'-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), alpha-L-LNA, or 2'-thio-LNA residues.

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12 December 2020

Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.

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12 December 2020

LNA: a versatile tool for therapeutics and genomics

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12 December 2020

Design and characterization of decoy oligonucleotides containing locked nucleic acids

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12 December 2020

Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

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12 December 2020

Implications of high-affinity hybridization by locked nucleic acid oligomers for inhibition of human telomerase

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12 December 2020

10.1016/J.DDTEC.2005.08.012

Identifiers

DOI

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21 March 2020

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