Chemical biology probes of mammalian GLUT structure and function (Q59329006)

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22 October 2019

15 December 2019

19 November 2020

4 February 2021

475

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issue

22

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page(s)

3511-3534

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copyright license

4 references

22 October 2019

15 December 2019

19 November 2020

4 February 2021

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Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitors

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12 December 2020

Evidence for two asymmetric conformational states in the human erythrocyte sugar-transport system

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12 December 2020

Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding

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12 December 2020

SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast

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12 December 2020

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester

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12 December 2020

Exofacial photolabelling of the human erythrocyte glucose transporter with an azitrifluoroethylbenzoyl-substituted bismannose.

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12 December 2020

Molecular cloning and characterization of an insulin-regulatable glucose transporter

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12 December 2020

Identification of a novel gene encoding an insulin-responsive glucose transporter protein

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12 December 2020

Photolabeling of erythrocyte and adipocyte hexose transporters using a benzophenone derivative of bis(D-mannose).

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12 December 2020

Proteolytic dissection as a probe of conformational changes in the human erythrocyte glucose transport protein

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12 December 2020

Mammalian and bacterial sugar transport proteins are homologous

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12 December 2020

Photolabelling of the hexose transporter at external and internal sites: fragmentation patterns and evidence for a conformational change

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12 December 2020

Binding of cytochalasin B to trypsin and thermolysin fragments of the human erythrocyte hexose transporter

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12 December 2020

Sequence and structure of a human glucose transporter

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12 December 2020

Interaction of hydrophobic bis (D-mannose) derivatives with adipocyte and erythrocyte sugar transport systems

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12 December 2020

Structural requirements for binding to the sugar-transport system of the human erythrocyte

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12 December 2020

An explanation of the asymmetric binding of sugars to the human erythrocyte sugar-transport systems

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12 December 2020

Kinetic parameters of glucose efflux from human red blood cells under zero-trans conditions

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12 December 2020

Simple Allosteric Model for Membrane Pumps

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12 December 2020

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site

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12 December 2020

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane

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12 December 2020

Symmetrical kinetic parameters for 3-O-methyl-D-glucose transport in adipocytes in the presence and in the absence of insulin.

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12 December 2020

Hydrogen bonding requirements for the insulin-sensitive sugar transport system of rat adipocytes.

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12 December 2020

Side-specific analogues for the rat adipocyte sugar transport system

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12 December 2020

The GLUT5 hexose transporter is also localized to the basolateral membrane of the human jejunum

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12 December 2020

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

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12 December 2020

Controlling Signal Transduction with Synthetic Ligands

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12 December 2020

Glucose transporter proteins in brain

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12 December 2020

Domain assembly of the GLUT1 glucose transporter

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12 December 2020

Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools.

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12 December 2020

Substitution of conserved tyrosine residues in helix 4 (Y143) and 7 (Y293) affects the activity, but not IAPS-forskolin binding, of the glucose transporter GLUT4.

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12 December 2020

Replacement of both tryptophan residues at 388 and 412 completely abolished cytochalasin B photolabelling of the GLUT1 glucose transporter

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12 December 2020

Substitution of tyrosine 293 of GLUT1 locks the transporter into an outward facing conformation

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12 December 2020

The glucose transporter family: structure, function and tissue-specific expression.

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12 December 2020

Substitution at Pro385 of GLUT1 perturbs the glucose transport function by reducing conformational flexibility

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12 December 2020

Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action

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12 December 2020

The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes

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12 December 2020

The use of biotinylation in the detection and purification of affinity labelled Glut-1.

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12 December 2020

Expression of the fructose transporter GLUT5 in human breast cancer

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12 December 2020

Identification of an amino acid residue that lies between the exofacial vestibule and exofacial substrate-binding site of the Glut1 sugar permeation pathway

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12 December 2020

Serine-294 and threonine-295 in the exofacial loop domain between helices 7 and 8 of glucose transporters (GLUT) are involved in the conformational alterations during the transport process.

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12 December 2020

Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale

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12 December 2020

Multiple endosomal recycling pathways in rat adipose cells

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12 December 2020

Cysteine-scanning mutagenesis of flanking regions at the boundary between external loop I or IV and transmembrane segment II or VII in the GLUT1 glucose transporter

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12 December 2020

Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited

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12 December 2020

Structural basis of activation and GTP hydrolysis in Rab proteins

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12 December 2020

Transmembrane segment 5 of the Glut1 glucose transporter is an amphipathic helix that forms part of the sugar permeation pathway

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12 December 2020

Signals from the reproductive system regulate the lifespan of C. elegans

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12 December 2020

Cysteine-scanning mutagenesis of transmembrane segment 7 of the GLUT1 glucose transporter

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12 December 2020

Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients

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12 December 2020

Synthesis and evaluation of fructose analogues as inhibitors of the D-fructose transporter GLUT5.

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12 December 2020

Insulin recruits GLUT4 from specialized VAMP2-carrying vesicles as well as from the dynamic endosomal/trans-Golgi network in rat adipocytes

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12 December 2020

Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling

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12 December 2020

Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin

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12 December 2020

Insulin and isoproterenol have opposing roles in the maintenance of cytosol pH and optimal fusion of GLUT4 vesicles with the plasma membrane

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12 December 2020

GLUT2 in pancreatic and extra-pancreatic gluco-detection (review).

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12 December 2020

Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: an example from glucose-transporter probes

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12 December 2020

Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.

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12 December 2020

Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5.

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12 December 2020

GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms

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12 December 2020

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

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12 December 2020

5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes

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12 December 2020

Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis

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12 December 2020

Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1.

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12 December 2020

On the Origin of Cancer Cells

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12 December 2020

Determination of the temperature and pH dependence of glucose transfer across the human erythrocyte membrane measured by glucose exit

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12 December 2020

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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12 December 2020

Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is GGA dependent

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12 December 2020

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes

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12 December 2020

Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes

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12 December 2020

Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity

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12 December 2020

Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells.

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12 December 2020

Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step.

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12 December 2020

From mice to men: insights into the insulin resistance syndromes

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12 December 2020

Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis

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12 December 2020

Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle

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12 December 2020

Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane

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12 December 2020

Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.

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12 December 2020

Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane

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12 December 2020

Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport.

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12 December 2020

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics

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12 December 2020

Endocrine regulation of ageing

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12 December 2020

A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity

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12 December 2020

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

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12 December 2020

Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation

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12 December 2020

Regulation of the fructose transporter GLUT5 in health and disease

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12 December 2020

GLUT7: a new intestinal facilitated hexose transporter

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12 December 2020

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

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12 December 2020

Functional studies of the T295M mutation causing Glut1 deficiency: glucose efflux preferentially affected by T295M.

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12 December 2020

Kinetics of GLUT4 trafficking in rat and human skeletal muscle

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12 December 2020

Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression

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12 December 2020

Uric acid transport and disease

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12 December 2020

Insulin-regulated trafficking of GLUT4 requires ubiquitination

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12 December 2020

Kinetic evidence that Glut4 follows different endocytic pathways than the receptors for transferrin and alpha2-macroglobulin

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12 December 2020

The sugar is sIRVed: sorting Glut4 and its fellow travelers

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12 December 2020

Dual-mode of insulin action controls GLUT4 vesicle exocytosis

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12 December 2020

Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes

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12 December 2020

Diversity of polyphenol action in Caenorhabditis elegans: between toxicity and longevity

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12 December 2020

Structural selectivity of human SGLT inhibitors

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12 December 2020

Regulation of glucose transporter translocation in health and diabetes

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12 December 2020

GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes.

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12 December 2020

Crystal structure of a bacterial homologue of glucose transporters GLUT1-4

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12 December 2020

Sequence determinants of GLUT1-mediated accelerated-exchange transport: analysis by homology-scanning mutagenesis

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12 December 2020

The role of fructose transporters in diseases linked to excessive fructose intake

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12 December 2020

Structural biology. (Pseudo-)symmetrical transport

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12 December 2020

A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes

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12 December 2020

The SLC2 (GLUT) family of membrane transporters

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12 December 2020

Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis

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12 December 2020

Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs

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12 December 2020

FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways

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12 December 2020

Crystal structure of the human glucose transporter GLUT1

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12 December 2020

“Deletion of both Rab-GTPase–activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport [corrected].

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12 December 2020

New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5.

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12 December 2020

Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes

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12 December 2020

Structural Symmetry in Membrane Proteins.

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12 December 2020

Molecular basis of ligand recognition and transport by glucose transporters

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12 December 2020

Structure and mechanism of the mammalian fructose transporter GLUT5

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12 December 2020

Understanding transport by the major facilitator superfamily (MFS): structures pave the way.

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12 December 2020

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

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12 December 2020

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876.

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12 December 2020

Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases

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12 December 2020

Tunable GLUT-Hexose Binding and Transport via Modulation of Hexose C-3 Hydrogen-Bonding Capabilities.

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12 December 2020

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

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12 December 2020

RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis

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12 December 2020

The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease.

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12 December 2020

Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters

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12 December 2020

Rab 10-a traffic controller in multiple cellular pathways and locations.

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12 December 2020

Multicolor GLUT5-permeable fluorescent probes for fructose transport analysis.

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12 December 2020

Targeting Sugar Uptake and Metabolism for Cancer Identification and Therapy: An Overview

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12 December 2020

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

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12 December 2020