Molecular mechanisms and potential functions of histone demethylases (Q59540864)

Crystal structure of the nucleosome core particle at 2.8 A resolution

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Roles of histone acetyltransferases and deacetylases in gene regulation

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Role of histone acetylation in cell physiology and diseases: An update

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

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Fast signals and slow marks: the dynamics of histone modifications

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Histone methyltransferases in cancer

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Histone demethylases in development and disease

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JmjC-domain-containing proteins and histone demethylation

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Epigenetic gene regulation by plant Jumonji group of histone demethylase.

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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

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Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36

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Organismal differences in post-translational modifications in histones H3 and H4.

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Expression patterns and post-translational modifications associated with mammalian histone H3 variants

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Methylation of H2AR29 is a novel repressive PRMT6 target

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Identification of lysine 37 of histone H2B as a novel site of methylation

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Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

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p53 is regulated by the lysine demethylase LSD1

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The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

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Lysine methylation regulates E2F1-induced cell death

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A novel mammalian flavin-dependent histone demethylase

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KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

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Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

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PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

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Crystal structure and mechanism of human lysine-specific demethylase-1.

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Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth

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The COMPASS family of H3K4 methylases in Drosophila

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An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation

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Histone demethylation by a family of JmjC domain-containing proteins

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The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

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Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

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Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

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RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

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A histone H3 lysine 27 demethylase regulates animal posterior development

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The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

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The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase.

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Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins.

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The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

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Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase

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The fission yeast Jmj2 reverses histone H3 Lysine 4 trimethylation

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Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation

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The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.

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JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

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The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases

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The retinoblastoma binding protein RBP2 is an H3K4 demethylase

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Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein

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PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

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Key roles of histone methyltransferase and demethylase in leukemogenesis.

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Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development

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Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary

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A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory

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Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

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Opposing LSD1 complexes function in developmental gene activation and repression programmes

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Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis

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Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.

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Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

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Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis

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The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice

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The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility

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Jarid1b targets genes regulating development and is involved in neural differentiation

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Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation

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Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice

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jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background

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In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse

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The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

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Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor

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Phosphatidylserine receptor is required for clearance of apoptotic cells

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Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly

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Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

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Phenotypic annotation of the mouse X chromosome

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UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program

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Histone demethylase JHDM2A is involved in male infertility and obesity

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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

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Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

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Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

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LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

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Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia

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Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation

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Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation

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A novel mutation in JARID1C gene associated with mental retardation

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A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD)

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A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay.

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Novel JARID1C/SMCX mutations in patients with X-linked mental retardation

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A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C.

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Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.

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Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

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Structural basis of LSD1-CoREST selectivity in histone H3 recognition

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Structural insights into histone demethylation by JMJD2 family members.

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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

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Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

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Structural basis of the recognition of a methylated histone tail by JMJD2A

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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

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A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation

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PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

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Structural insights into a novel histone demethylase PHF8

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Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4.

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KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

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High throughput characterization of combinatorial histone codes

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Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

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Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans

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Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

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Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.

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JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

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The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

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Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

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Regulation of LSD1 histone demethylase activity by its associated factors

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LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.

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Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries

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Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

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CpG islands recruit a histone H3 lysine 36 demethylase

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Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells

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RBP2-H1/JARID1B is a transcriptional regulator with a tumor suppressive potential in melanoma cells

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KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription

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Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

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PHF8 targets histone methylation and RNA polymerase II to activate transcription.

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Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

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Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

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Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase

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KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

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Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions

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The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2.

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Identification of histone demethylases in Saccharomyces cerevisiae.

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

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p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation.

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Methylation-mediated regulation of E2F1 in DNA damage-induced cell death

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Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

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Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

31 March 2020

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Inactive yet indispensable: the tale of Jarid2.

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Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

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Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

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JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

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JMJD6 is a histone arginine demethylase

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Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

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Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation

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Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression

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Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock

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Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A

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Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor

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Molecular recognition of H3/H4 histone tails by the tudor domains of JMJD2A: a comparative molecular dynamics simulations study

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Keeping it in the family: diverse histone recognition by conserved structural folds

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DNA-binding properties of ARID family proteins

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The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif

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Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions

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Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1

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A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development

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Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

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Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.

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Functional antagonism between histone H3K4 demethylases in vivo

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Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3

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PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

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PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

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The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein

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SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation.

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PARP inhibition: PARP1 and beyond

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The roles of PARP1 in gene control and cell differentiation

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The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

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Histone modification: cause or cog?

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Stability of histone modifications across mammalian genomes: implications for 'epigenetic' marking

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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

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Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

31 March 2020

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Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

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FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway

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Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma

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Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck

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Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

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A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

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Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate

31 March 2020

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Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells

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Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

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The expression of histone demethylase JMJD1A in renal cell carcinoma

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Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

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Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

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Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome

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Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis

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The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma

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Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor.

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Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

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Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components

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Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.

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Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene

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The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis

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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

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A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

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PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?

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Jumonji, a nuclear protein that is necessary for normal heart development

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Generation of a conditional null allele of jumonji.

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Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate

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Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects

31 March 2020

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Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer

31 March 2020

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Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role

31 March 2020

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