Selective effects of NF-κB1 deficiency in CD4+ T cells on Th2 and TFh induction by alum-precipitated protein vaccines (Q60171270)

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27 January 2020

title

Selective effects of NF-κB1 deficiency in CD4⁺ T cells on Th2 and TFh induction by alum-precipitated protein vaccines (English)

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1

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Elodie Mohr

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27 January 2020

Cecile Bénézech

3

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27 January 2020

Jorge H Caamano

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author name string

Roger Bird

4

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27 January 2020

Mahmood Khan

5

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Adam F Cunningham

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27 January 2020

Ian C M Maclennan

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language of work or name

English

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publication date

25 May 2011

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European Journal of Immunology

27 January 2020

published in

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volume

41

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issue

6

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page(s)

1573-1582

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Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction.

27 January 2020

cites work

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Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.

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Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature.

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Follicular B helper T cells in antibody responses and autoimmunity.

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How are T(H)2-type immune responses initiated and amplified?

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Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells

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In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation

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7 January 2021

NF-kappaB regulation in the immune system

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Differential Requirement for NF- B Family Members in Control of Helminth Infection and Intestinal Inflammation

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7 January 2021

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

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7 January 2021

Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation

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Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiation

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7 January 2021

NF-kappa B1 is required for optimal CD4+ Th1 cell development and resistance to Leishmania major.

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7 January 2021

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation

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7 January 2021

Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival

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7 January 2021

Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella.

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7 January 2021

IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo

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7 January 2021

In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

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7 January 2021

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

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7 January 2021

Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly responding central-memory-like CD4 T cells.

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7 January 2021

GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

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7 January 2021

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

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7 January 2021

Cutting edge: Ikaros is a regulator of Th2 cell differentiation

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7 January 2021

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

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7 January 2021

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

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7 January 2021

Bcl6 mediates the development of T follicular helper cells

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7 January 2021

NF-kappa B RelA (p65) is essential for TNF-alpha-induced fas expression but dispensable for both TCR-induced expression and activation-induced cell death

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7 January 2021

Controlling NF-kappaB activation in T cells by costimulatory receptors

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7 January 2021

Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis

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7 January 2021

Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo

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7 January 2021

OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation

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7 January 2021

OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.

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7 January 2021

CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

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7 January 2021

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.

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7 January 2021

CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

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7 January 2021

Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

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7 January 2021

Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.

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7 January 2021

Cytokine-secreting follicular T cells shape the antibody repertoire

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7 January 2021

IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

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7 January 2021

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

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7 January 2021

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

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7 January 2021

SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1

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7 January 2021

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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7 January 2021

Identifiers

DOI

10.1002/EJI.201041126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21469117%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

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