Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation (Q28252247)

1

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Amanda C Poholek

2

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Daniel DiToro

3

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Isharat Yusuf

4

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Danelle Eto

5

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Burton Barnett

6

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Alexander L Dent

7

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Joe Craft

T follicular helper cells differentiate from Th2 cells in response to helminth antigens

8

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language of work or name

English

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publication date

21 August 2009

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published in

Science

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volume

325

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page(s)

1006-10

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issue

5943

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cites work

1 reference

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

20 March 2017

1 reference

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Regulation and functions of Blimp-1 in T and B lymphocytes

20 March 2017

1 reference

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

20 March 2017

1 reference

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A chemokine-driven positive feedback loop organizes lymphoid follicles

20 March 2017

1 reference

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BCL-6 protein is expressed in germinal-center B cells

20 March 2017

1 reference

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SAP is required for generating long-term humoral immunity

20 March 2017

1 reference

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The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

20 March 2017

1 reference

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Control of inflammation, cytokine expression, and germinal center formation by BCL-6

20 March 2017

1 reference

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IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Cytokine-secreting follicular T cells shape the antibody repertoire

29 September 2017

1 reference

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SLAM receptors and SAP influence lymphocyte interactions, development and function

29 September 2017

1 reference

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CD4 T cells: fates, functions, and faults

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

A fundamental role for interleukin-21 in the generation of T follicular helper cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

T follicular helper (TFH) cells in normal and dysregulated immune responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Germinal centres: role in B-cell physiology and malignancy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Follicular B helper T cells in antibody responses and autoimmunity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Immune responses of IL-4, IL-5, IL-6 deficient mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2766560

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

2 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1175870

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1175870

Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1175870

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1175870

In Vivo Generated Th1 Cells Can Migrate to B Cell Follicles to Support B Cell Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1175870

Th1 and Th2 CD4+ T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo

21 January 2018

1 reference

12 December 2020

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

1 reference

12 December 2020

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

1 reference

12 December 2020

Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

1 reference

12 December 2020

Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression

1 reference

12 December 2020

Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.1175870

1 reference

release_c5kpy66qtjasjkqps5mlbelnha

530758

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/c5kpy66qtjasjkqps5mlbelnha

24 November 2022

mapped directly with Wikidata item

530758

1 reference

1 reference

1 reference