Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole (Q60894849)

Ortholog(s) have role in negative regulation of cellular response to oxidative stress

5 February 2019

1 reference

Putative c-14 sterol reductase with a predicted role in ergosterol biosynthesis

5 February 2019

1 reference

Putative major facilitator superfamily (MFS) transporter

5 February 2019

1 reference

Has domain(s) with predicted hydrolase activity

5 February 2019

1 reference

Putative c-14 sterol reductase with a predicted role in ergosterol biosynthesis

5 February 2019

1 reference

Putative sterol o-acyltransferase

5 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN4248, AN4636, A. fumigatus Af293 : Afu2g02480, A. niger CBS 513.88 : An18g05540 and A. oryzae RIB40 : AO090001000452, AO090026000570

5 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN4252, AN10165, A. fumigatus Af293 : Afu1g11910, A. niger CBS 513.88 : An18g05640, An08g04120 and A. oryzae RIB40 : AO090001000456, AO090001000373

5 February 2019

1 reference

Putative C-24(28) sterol reductase

5 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN5103, A. niger CBS 513.88 : An07g10393, A. oryzae RIB40 : AO090012001023, Neosartorya fischeri NRRL 181 : NFIA_017020 and Aspergillus versicolor : Aspve1_0139230

5 February 2019

1 reference

Mitochondrial inner membrane translocase subunit

5 February 2019

1 reference

putative ABC multidrug transporter

5 February 2019

1 reference

Putative neutral amino acid permease

5 February 2019

1 reference

Putative ammonium transporter

5 February 2019

1 reference

Heat shock protein/chaperonin

5 February 2019

1 reference

Putative toxin efflux pump

5 February 2019

1 reference

Putative nitrite reductase

5 February 2019

1 reference

5 February 2019

1 reference

Ortholog(s) have nucleotidyltransferase activity

5 February 2019

1 reference

Has domain(s) with predicted role in intracellular protein transport and intracellular localization

5 February 2019

Putative F-box protein

1 reference

5 February 2019

1 reference

5 February 2019

1 reference

Transcription initiation factor IID

5 February 2019

1 reference

5 February 2019

1 reference

5 February 2019

1 reference

5 February 2019

Putative lipase/esterase

1 reference

Putative major facilitator superfamily (MFS) transporter

5 February 2019

1 reference

Ortholog of A. niger CBS 513.88 : An12g03130, A. oryzae RIB40 : AO090120000028, Neosartorya fischeri NRRL 181 : NFIA_009090 and Aspergillus wentii : Aspwe1_0053463

5 February 2019

1 reference

Putative C2H2 transcription factor

5 February 2019

1 reference

Conidial cell wall hydrophobin involved in conidial cell wall composition

5 February 2019

1 reference

Putative transmembrane domain protein

5 February 2019

1 reference

Putative vacuolar ABC heavy metal transporter

5 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN1871, A. niger CBS 513.88 : An11g03160, A. oryzae RIB40 : AO090003000240, Aspergillus wentii : Aspwe1_0177180 and Aspergillus sydowii : Aspsy1_0140729

5 February 2019

1 reference

Putative tyrosine decarboxylase

5 February 2019

1 reference

Putative ammonium transporter

5 February 2019

1 reference

Ortholog(s) have role in cation homeostasis

5 February 2019

1 reference

5 February 2019

1 reference

5 February 2019

1 reference

Transcript downregulated in response to voriconazole

5 February 2019

1 reference

Putative alpha(1-3) glucan synthase

5 February 2019

1 reference

5 February 2019

1 reference

5 February 2019

Putative endoglucanase

1 reference

5 February 2019

Putative endo-arabinase

1 reference

Putative BCS1-like ATPase

5 February 2019

1 reference

Ortholog(s) have ATP binding, drug binding, drug transmembrane transporter activity, fluconazole transporter activity, phospholipid-translocating ATPase activity

5 February 2019

1 reference

Small oligopeptide transporter

5 February 2019

1 reference

Conidia-enriched protein of unknown function

5 February 2019

1 reference

5 February 2019

1 reference

Putative extracellular aspartic endopeptidase

5 February 2019

1 reference

5 February 2019

Putative phospholipase D

1 reference

Putative major facilitator superfamily (MFS) multidrug transporter

5 February 2019

1 reference

5 February 2019

1 reference

Ortholog(s) have role in cellular response to drug

5 February 2019

1 reference

5 February 2019

multicopper oxidase abr1

1 reference

5 February 2019

1 reference

Putative integral membrane protein

5 February 2019

1 reference

5 February 2019

1 reference

5 February 2019

Ortholog of Aspergillus fumigatus A1163 : AFUB_048010

1 reference

5 February 2019

1 reference

Protein with Yap1-dependent induction in response to hydrogen peroxide

6 February 2019

1 reference

Ortholog(s) have role in conidiophore development, conidium formation, hyphal growth, sporocarp development involved in sexual reproduction

6 February 2019

1 reference

Ortholog of A. oryzae RIB40 : AO090701000673, Aspergillus flavus NRRL 3357 : AFL2T_06266, Neosartorya fischeri NRRL 181 : NFIA_001900 and Aspergillus versicolor : Aspve1_0437730

6 February 2019

1 reference

Putative integral membrane protein

6 February 2019

1 reference

putative 3-methyl-2-oxobutanoate dehydrogenase

6 February 2019

1 reference

Ortholog of Aspergillus fumigatus A1163 : AFUB_046900

6 February 2019

1 reference

Ortholog of Aspergillus fumigatus A1163 : AFUB_046590

6 February 2019

1 reference

Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization

6 February 2019

1 reference

Has domain(s) with predicted protein-arginine deiminase activity and role in putrescine biosynthetic process

6 February 2019

1 reference

Predicted adhesin-like protein

6 February 2019

1 reference

Has domain(s) with predicted DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, zinc ion binding activity and role in regulation of transcription, DNA-templated, transcription, DNA-templated

6 February 2019

1 reference

Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization

6 February 2019

1 reference

6 February 2019

1 reference

Has domain(s) with predicted role in response to stress and integral component of membrane localization

6 February 2019

1 reference

Putative vacuolar carboxypeptidase

6 February 2019

1 reference

Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport

6 February 2019

1 reference

6 February 2019

UDP-glucose 4-epimerase

1 reference

C2H2 transcription factor

6 February 2019

1 reference

Ortholog(s) have cytoplasm, nucleus localization

6 February 2019

1 reference

Putative endo 1,5-alpha-arabinase

6 February 2019

1 reference

Has domain(s) with predicted oxidoreductase activity and role in metabolic process

6 February 2019

1 reference

Has domain(s) with predicted nucleic acid binding, nucleotide binding activity

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN4989, A. niger CBS 513.88 : An16g03710, Aspergillus sydowii : Aspsy1_0042878 and Aspergillus terreus NIH2624 : ATET_04521

6 February 2019

1 reference

6 February 2019

1 reference

Putative hydroxymethyl glutaryl-coenzyme A synthase with a predicted role in ergosterol biosynthesis

6 February 2019

1 reference

6 February 2019

1 reference

C2H2 transcription factor with a role in conidiophore development, pigment production, germination and virulence

6 February 2019

1 reference

Ortholog of Neosartorya fischeri NRRL 181 : NFIA_062910 and Aspergillus fumigatus A1163 : AFUB_034830

6 February 2019

1 reference

Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization

6 February 2019

1 reference

Putative secreted lysophospholipase B

6 February 2019

1 reference

Extracellular chitosanase

6 February 2019

1 reference

2-oxoglutarate-Fe(II) type oxidoreductase

6 February 2019

1 reference

Putative mitochondrial chaperone ATPase involved in the assembly of mitochondrial respiratory chain complex III

6 February 2019

1 reference

Glycosyl hydrolase family 75 chitosanase

6 February 2019

1 reference

Putative ankyrin repeat protein

6 February 2019

1 reference

Ortholog(s) have dipeptidyl-peptidase activity and cytoplasm, nucleus localization

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

1 reference

14-alpha sterol demethylase

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN3529, AN4144, AN8311, AN9211, AN4846 and A. fumigatus Af293 : Afu1g17260, Afu4g09380, Afu6g00560, Afu6g12140, Afu8g01900

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN1719, A. niger CBS 513.88 : An04g03180, A. oryzae RIB40 : AO090701000366, Aspergillus wentii : Aspwe1_0102057, Aspwe1_0436878 and Aspergillus sydowii : Aspsy1_0074793

6 February 2019

1 reference

Putative short chain dehydrogenase

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

Putative high affinity methionine permease

1 reference

Putative S-adenosyl-methionine-sterol-C methyltransferase

6 February 2019

1 reference

Small Cell Wall Peptide A

6 February 2019

1 reference

6 February 2019

1 reference

Has domain(s) with predicted phosphoric diester hydrolase activity and role in lipid metabolic process

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

Psi-producing oxygenase A

1 reference

Transcriptional activator of the cross-pathway control system of amino acid biosynthesis

6 February 2019

1 reference

MFS monosaccharide transporter

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN5168, AN1130, A. fumigatus Af293 : Afu6g07030, A. niger CBS 513.88 : An15g06750, An07g01930 and A. oryzae RIB40 : AO090701000916

6 February 2019

1 reference

Secreted protein of unknown function

6 February 2019

1 reference

6 February 2019

1 reference

Putative zinc transporter

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN7822, Neosartorya fischeri NRRL 181 : NFIA_041410, Aspergillus wentii : Aspwe1_0052659 and Aspergillus versicolor : Aspve1_0026333, Aspve1_0046552

6 February 2019

1 reference

Has domain(s) with predicted ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances, nucleoside-triphosphatase activity, nucleotide binding activity and role in transport

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization

1 reference

6 February 2019

1 reference

6 February 2019

1 reference

Putative multidrug resistant protein

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN2683, AN5069, A. fumigatus Af293 : Afu5g14320, A. niger CBS 513.88 : An09g04830, An14g05730 and A. oryzae RIB40 : AO090102000482, AO090001000197

6 February 2019

1 reference

Putative aromatic amino acid aminotransferase

6 February 2019

1 reference

6 February 2019

1 reference

Putative oxidosqualene:lanosterol cyclase (OSLC) with a role in protostadienol biosynthesis

6 February 2019

1 reference

ABC multidrug transporter

6 February 2019

1 reference

4-aminobutyrate aminotransferase

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN10975, A. niger CBS 513.88 : An17g00170, A. oryzae RIB40 : AO090701000290, Aspergillus versicolor : Aspve1_0135244 and Aspergillus clavatus NRRL 1 : ACLA_010110

6 February 2019

1 reference

Ribosome biogenesis ABC transporter

6 February 2019

1 reference

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN11018, A. niger CBS 513.88 : An03g03930, A. oryzae RIB40 : AO090701000702, Aspergillus wentii : Aspwe1_0167560 and Aspergillus sydowii : Aspsy1_0058760

6 February 2019

1 reference

6 February 2019

1 reference

Has domain(s) with predicted ATP binding, ATPase activity, nucleoside-triphosphatase activity, nucleotide binding activity

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

Ortholog(s) have role in secondary metabolite biosynthetic process

1 reference

6 February 2019

1 reference

6 February 2019

Ortholog of A. nidulans FGSC A4 : AN11144, AN8627, AN11697, A. fumigatus Af293 : Afu8g07260, A. niger CBS 513.88 : An09g01560, An12g10160 and A. oryzae RIB40 : AO090003001375, AO090701000504, AO090102000039

1 reference

6 February 2019

1 reference

6 February 2019

1 reference

Putative extracellular arabinanase

6 February 2019

1 reference

Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization

6 February 2019

1 reference

6 February 2019

Putative cytochrome P450

1 reference

Putative cell wall glucanase

6 February 2019

1 reference

fructosyl amino acid oxidase, putative

6 February 2019

1 reference

6 February 2019

N-methyltransferase fmpB

1 reference

fumipyrrole biosynthesis protein C

6 February 2019

1 reference

putative MDR1 family ABC transporter

6 February 2019

1 reference

6 February 2019

1 reference

Putative aspartic-type endopeptidase

6 February 2019

1 reference

Putative integral plasma membrane heat shock protein

6 February 2019

1 reference

Ortholog(s) have role in fungal-type cell wall organization, protein oligomerization and Golgi apparatus, cell cortex of cell tip, cell division site, cellular bud, membrane raft, plasma membrane localization

6 February 2019

1 reference

Has domain(s) with predicted role in transmembrane transport and integral component of membrane localization

6 February 2019

1 reference

Putative N,O-diacetyl muramidase

6 February 2019

1 reference

Predicted GPI anchored protein

6 February 2019

1 reference

Ortholog(s) have endoplasmic reticulum localization

6 February 2019

1 reference

Protein of unknown function identified by mass spectrometry

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

nonribosomal peptide synthetase 11

1 reference

flavoprotein amide oxidase (FAD)

6 February 2019

1 reference

Putative adenylate-forming enzyme

6 February 2019

1 reference

Ortholog of A. nidulans FGSC A4 : AN6413, AN6419, AN6946, AN5312, AN5664, AN8328, AN3241, AN10369, AN1930, AN2386, AN1738, AN11159, AN8984, AN8951, AN1540, AN8971, AN9387, AN9266, AN9306, AN1317, AN10886, AN7232, AN7774, AN12202

6 February 2019

1 reference

Putative acetyl-CoA acetyltransferase

6 February 2019

1 reference

6 February 2019

Putative ABC transporter

1 reference

Putative NACHT and ankyrin domain protein

6 February 2019

1 reference

Ortholog(s) have role in filamentous growth, growth of symbiont in host

6 February 2019

1 reference

Putative 14-alpha demethylase with a predicted role in ergosterol biosynthesis

6 February 2019

1 reference

Ortholog(s) have endoplasmic reticulum localization

6 February 2019

1 reference

Ortholog of A. nidulans AN8062

6 February 2019

1 reference

6 February 2019

1 reference

Putative theta class glutathione transferase

6 February 2019

1 reference

Putative threonine aldolase

6 February 2019

1 reference

Putative zinc/cadmium resistance protein

6 February 2019

1 reference

6 February 2019

Ortholog of A. niger CBS 513.88 : An10g00280, Aspergillus tubingensis : Asptu1_0053817, Aspergillus fumigatus A1163 : AFUB_097670, AFUB_098030 and Aspergillus sydowii : Aspsy1_0041373

1 reference

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

1 reference

6 February 2019

putative cytochrome P450

1 reference

C6 finger transcription factor fumR

6 February 2019

1 reference

PKS-NRPS hybrid synthetase psoA

6 February 2019

1 reference

cytochrome P450 monooxygenase psoD

6 February 2019

1 reference

Putative cell surface protein

6 February 2019

1 reference

Putative amino acid transporter

6 February 2019

1 reference

6 February 2019

1 reference

Antigenic thaumatin domain protein

6 February 2019

1 reference

6 February 2019

1 reference

Putative beta(1-3)glucanosyltransferase, belongs to the 7-member GEL family

6 February 2019

1 reference

Putative MFS peptide transporter

6 February 2019

1 reference

Putative C2H2 zinc-finger transcription factor

6 February 2019

1 reference

Putative major facilitator superfamily (MFS) sugar transporter

6 February 2019

1 reference

C6 zinc finger domain protein

6 February 2019

1 reference

Ortholog of Aspergillus brasiliensis : Aspbr1_0060310, Aspergillus glaucus : Aspgl1_1496032, Neosartorya fischeri NRRL 181 : NFIA_069850 and Aspergillus fumigatus A1163 : AFUB_001950

6 February 2019

1 reference

Putative esterase family protein

6 February 2019

1 reference

Putative alpha-1,3-glucanase

6 February 2019

1 reference

hydroxymethylglutaryl-CoA synthase

6 February 2019

1 reference

6 February 2019

1 reference

Aspergillus fumigatus

object named as

Aspergillus fumigatus

1 reference

4

Axel A Brakhage

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Axel A Brakhage

4

object named as

Axel A. Brakhage

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author name string

Márcia Eliana da Silva Ferreira

1

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Iran Malavazi

2

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Marcela Savoldi

3

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Maria Helena S. Goldman

5

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H. Stanley Kim

6

0 references

William C. Nierman

7

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Gustavo H. Goldman

8

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Maria Helena S Goldman

5

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H Stanley Kim

6

0 references

William C Nierman

7

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Gustavo H Goldman

https://scigraph.springernature.com/pub.10.1007/s00294-006-0073-2

8

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language of work or name

English

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publication date

19 April 2006

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July 2006

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published in

Current Genetics

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volume

50

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issue

1

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page(s)

32-44

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exact match

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cites work

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12 December 2020

Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans

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12 December 2020

Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase

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12 December 2020

Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14alpha-demethylase gene, pdmA.

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12 December 2020

The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.

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12 December 2020

Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent

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A novel method used to delete a new Aspergillus fumigatus ABC transporter-encoding gene.

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Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

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Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans

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AAA+ proteins: have engine, will work

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12 December 2020

Identification, cloning, and functional expression of three glutathione transferase genes from Aspergillus fumigatus

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12 December 2020

Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol

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12 December 2020

Quality control and reference guidelines for CLSI broth microdilution susceptibility method (M 38-A document) for amphotericin B, itraconazole, posaconazole, and voriconazole

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12 December 2020

Isolation and characterization of fluconazole- and amphotericin B-resistant Candida albicans from blood of two patients with leukemia

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12 December 2020

Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans

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12 December 2020

The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus

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12 December 2020

Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation

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12 December 2020

Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

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12 December 2020

Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis Inhibitors

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12 December 2020

Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters

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12 December 2020

Response of gene expression in Saccharomyces cerevisiae to amphotericin B and nystatin measured by microarrays

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12 December 2020

Genomic profiling of the response of Candida albicans to itraconazole treatment using a DNA microarray

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12 December 2020

The cAMP signal transduction pathway mediates resistance to dicarboximide and aromatic hydrocarbon fungicides in Ustilago maydis

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12 December 2020

Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates

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12 December 2020

Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients

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12 December 2020

Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus

1 reference

12 December 2020

Cyclic AMP and fluconazole resistance in Saccharomyces cerevisiae

1 reference

12 December 2020

Three putative oxylipin biosynthetic genes integrate sexual and asexual development in Aspergillus nidulans

1 reference

12 December 2020

Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae

1 reference

12 December 2020

Acquired itraconazole resistance in Aspergillus fumigatus

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12 December 2020

Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents

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12 December 2020

cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages

1 reference

12 December 2020

Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

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12 December 2020

Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence

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A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus

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Meiotic and Mitotic Recombination in Aspergillus and Its Chromosomal Aberrations

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Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence.

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Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis

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12 December 2020

Quantitative analysis of the relative transcript levels of ABC transporter Atr genes in Aspergillus nidulans by real-time reverse transcription-PCR assay

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12 December 2020

Molecular basis of resistance to azole antifungals

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12 December 2020

Itraconazole resistance in Aspergillus fumigatus

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12 December 2020

The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen

1 reference

12 December 2020

Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

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