Mesenchymal Stem Cells-derived Exosomes: A New Possible Therapeutic Strategy for Parkinson's Disease? (Q64246124)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30717429%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

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8 October 2022

Mesenchymal Stem Cells-derived Exosomes: A New Possible Therapeutic Strategy for Parkinson's Disease? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30717429%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

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mesenchymal stem cell

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21 April 2020

Fábio Gabriel Teixeira

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3

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21 April 2020

author name string

Helena Vilaça-Faria

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English

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2 February 2019

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21 April 2020

8 October 2022

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21 April 2020

8 October 2022

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21 April 2020

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Creative Commons Attribution

21 April 2020

page(s)

118

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8 October 2022

Levodopa with benserazide or carbidopa in Parkinson disease

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12 December 2020

Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease.

1 reference

12 December 2020

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

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12 December 2020

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12 December 2020

Transferrin recycling in reticulocytes: pH and iron are important determinants of ligand binding and processing

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12 December 2020

Biochemical aspects of Parkinson's disease

1 reference

12 December 2020

Staging of brain pathology related to sporadic Parkinson's disease

1 reference

12 December 2020

Ropinirole as an adjunct to levodopa in the treatment of Parkinson's disease: a 16-week bromocriptine controlled study

1 reference

12 December 2020

Genetic and environmental factors in the cause of Parkinson's disease

1 reference

12 December 2020

Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease

1 reference

12 December 2020

Dicer is essential for mouse development

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12 December 2020

Stages in the development of Parkinson's disease-related pathology

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12 December 2020

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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12 December 2020

Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

1 reference

12 December 2020

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

12 December 2020

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

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12 December 2020

Advances in the treatment of Parkinson's disease

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12 December 2020

Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing.

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12 December 2020

A MicroRNA feedback circuit in midbrain dopamine neurons

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12 December 2020

Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy

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12 December 2020

Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein

1 reference

12 December 2020

Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease

1 reference

12 December 2020

LRRK2 and neurodegeneration

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12 December 2020

Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum.

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12 December 2020

Revisiting the principles of microRNA target recognition and mode of action

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12 December 2020

Lesions outside the CNS in Parkinson's disease

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12 December 2020

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

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12 December 2020

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12 December 2020

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

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12 December 2020

Role of human umbilical cord mesenchymal progenitors conditioned media in neuronal/glial cell densities, viability, and proliferation

1 reference

12 December 2020

Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study

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12 December 2020

Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

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12 December 2020

Ageing, neurodegeneration and Parkinson's disease

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12 December 2020

Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153

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12 December 2020

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

1 reference

12 December 2020

MicroRNAs and deregulated gene expression networks in neurodegeneration

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12 December 2020

Cell-based therapeutic approaches for Parkinson's disease: progress and perspectives

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12 December 2020

Clinical progression in Parkinson disease and the neurobiology of axons.

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12 December 2020

Exosomes: extracellular organelles important in intercellular communication

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12 December 2020

MicroRNAs: synthesis, mechanism, function, and recent clinical trials

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12 December 2020

The widespread regulation of microRNA biogenesis, function and decay

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12 December 2020

Mesenchymal stem cells for the treatment of neurodegenerative disease.

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12 December 2020

Deep brain stimulation in Parkinson's disease.

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12 December 2020

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function

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12 December 2020

Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons

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12 December 2020

The secretome of bone marrow mesenchymal stem cells-conditioned media varies with time and drives a distinct effect on mature neurons and glial cells (primary cultures).

1 reference

12 December 2020

The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

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12 December 2020

The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations

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12 December 2020

Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth

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12 December 2020

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

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12 December 2020

Pathogenesis of Parkinson's disease

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12 December 2020

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

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12 December 2020

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

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12 December 2020

Parkinson disease: from pathology to molecular disease mechanisms.

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12 December 2020

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.

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12 December 2020

Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

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12 December 2020

Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo

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12 December 2020

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

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12 December 2020

Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations.

1 reference

12 December 2020

Rotigotine transdermal patch in Parkinson's disease: a systematic review and meta-analysis

1 reference

12 December 2020

Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats

1 reference

12 December 2020

Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics

1 reference

12 December 2020

Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications

1 reference

12 December 2020

Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival

1 reference

12 December 2020

MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration.

1 reference

12 December 2020

Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model.

1 reference

12 December 2020

Mesenchymal stem cells secrete immunologically active exosomes

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12 December 2020

miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling.

1 reference

12 December 2020

Emerging therapies for Parkinson's disease: from bench to bedside.

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12 December 2020

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

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12 December 2020

The prevalence of Parkinson's disease: a systematic review and meta-analysis

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12 December 2020

miR-16-1 promotes the aberrant α-synuclein accumulation in parkinson disease via targeting heat shock protein 70.

1 reference

12 December 2020

miR-7 and miR-153 protect neurons against MPP(+)-induced cell death via upregulation of mTOR pathway

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12 December 2020

Functions and application of exosomes.

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12 December 2020

Anti-inflammatory Mechanism of Bone Marrow Mesenchymal Stem Cell Transplantation in Rat Model of Spinal Cord Injury

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12 December 2020

Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation.

1 reference

12 December 2020

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

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12 December 2020

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12 December 2020

Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease

1 reference

12 December 2020

Dopaminergic modulation of motor network dynamics in Parkinson's disease

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12 December 2020

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

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12 December 2020

Exosome-mediated inflammasome signaling after central nervous system injury

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12 December 2020

Role of apomorphine in the treatment of Parkinson's disease

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12 December 2020

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

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12 December 2020

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine-induced apoptosis.

1 reference

12 December 2020

50 years of levodopa.

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12 December 2020

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

1 reference

12 December 2020

Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of Wharton Jelly mesenchymal stem cell secretome?

1 reference

12 December 2020

Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities

1 reference

12 December 2020

Treating non-motor symptoms of Parkinson's disease with transplantation of stem cells

1 reference

12 December 2020

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

1 reference

12 December 2020

The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress

1 reference

12 December 2020

Mesenchymal stem cells and immunomodulation: current status and future prospects

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12 December 2020

Extracellular vesicles round off communication in the nervous system

1 reference

12 December 2020

microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.

1 reference

12 December 2020

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease

1 reference

12 December 2020

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

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12 December 2020

Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis

1 reference

12 December 2020

MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease

1 reference

12 December 2020

Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation

1 reference

12 December 2020

Mesenchymal stromal cells as multifunctional cellular therapeutics - a potential role for extracellular vesicles

1 reference

12 December 2020

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

1 reference

12 December 2020

MSCs-Derived Exosomes: Cell-Secreted Nanovesicles with Regenerative Potential

1 reference

12 December 2020

Monoamine Oxidase B Inhibitors in Parkinson's Disease.

1 reference

12 December 2020

Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease

1 reference

12 December 2020

MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

1 reference

12 December 2020

The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models

1 reference

12 December 2020

Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis

1 reference

12 December 2020

Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator

1 reference

12 December 2020

Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science.

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12 December 2020

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF.

1 reference

12 December 2020

MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson's Disease

1 reference

12 December 2020

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

1 reference

12 December 2020

An updated meta-analysis of amantadine for treating dyskinesia in Parkinson's disease

1 reference

12 December 2020

Exosomes: Mechanisms of Uptake.

1 reference

12 December 2020

Oxidative stress and cellular pathologies in Parkinson's disease.

1 reference

12 December 2020

Safinamide: a new hope for Parkinson's disease?

1 reference

12 December 2020

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine.

1 reference

12 December 2020

Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease.

1 reference

12 December 2020

Exploiting the impact of the secretome of MSCs isolated from different tissue sources on neuronal differentiation and axonal growth

1 reference

12 December 2020

Opicapone for the treatment of Parkinson's disease: A review of a new licensed medicine

1 reference

12 December 2020

Influence of Passage Number on the Impact of the Secretome of Adipose Tissue Stem Cells on Neural Survival, Neurodifferentiation and Axonal Growth

1 reference

12 December 2020

Identifiers

DOI

10.3390/CELLS8020118

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30717429%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30717429%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

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