Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study (Q64379100)

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scientific article published on 01 January 2005

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English	Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study	scientific article published on 01 January 2005

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6 January 2020

Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study (English)

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John Nemunaitis

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C Casey Cunningham

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Sunil Chada

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James A Merritt

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Alex Tong

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Neil Senzer

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Yuan Zhang

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Abner Mhashilkar

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Karen Parker

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Sasha Vukelja

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Don Richards

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Jill Hood

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Keith Coffee

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Molecular Therapy

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6 January 2020

The family of IL-10-related cytokines and their receptors: related, but to what extent?

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MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.

1 reference

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The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24.

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Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy

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Down-regulated melanoma differentiation associated gene (mda-7) expression in human melanomas

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Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro

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The melanoma differentiation associated gene mda-7 suppresses cancer cell growth

1 reference

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The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice

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Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo

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Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation

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Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu-overexpressing breast cancer cells

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Prognostic value of K-ras mutations, ras oncoprotein, and c-erb B-2 oncoprotein expression in adenocarcinoma of the lung

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Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity

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The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells

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Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives

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Loss of MDA-7 expression with progression of melanoma

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MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells

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Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL

1 reference

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The MUC gene family: their role in diagnosis and early detection of pancreatic cancer

1 reference

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Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells

1 reference

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Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism

1 reference

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Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

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10.1016/J.YMTHE.2004.09.019

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6 January 2020

1 reference

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6 January 2020

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