SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. (Q64955772)

1 July 2019

title

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. (English)

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2

Richard G Pestell

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author name string

Heather L Montie

series ordinal

1

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Diane E Merry

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3

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publication date

1 November 2011

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1 July 2019

published in

Journal of Neuroscience

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1 July 2019

volume

31

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issue

48

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1 July 2019

page(s)

17425-17436

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Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

cites work

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12 December 2020

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

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12 December 2020

Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment

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12 December 2020

Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth

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12 December 2020

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

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12 December 2020

Hormonal control of androgen receptor function through SIRT1

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12 December 2020

After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders

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12 December 2020

Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

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12 December 2020

Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts

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12 December 2020

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

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12 December 2020

Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

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12 December 2020

Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells

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12 December 2020

Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy

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12 December 2020

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

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12 December 2020

Tip60 promotes prostate cancer cell proliferation by translocation of androgen receptor into the nucleus

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12 December 2020

An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy

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12 December 2020

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

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12 December 2020

FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases

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12 December 2020

Androgen receptor as a therapeutic target

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12 December 2020

Mammalian sirtuins: biological insights and disease relevance

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12 December 2020

Acetylation targets mutant huntingtin to autophagosomes for degradation

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12 December 2020

A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences

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12 December 2020

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

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12 December 2020

Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein

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12 December 2020

Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy

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12 December 2020

New observation on androgen action: androgen receptor stabilization and antisteroid effects of LHRH agonists

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12 December 2020

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

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12 December 2020

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

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12 December 2020

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

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12 December 2020

The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity.

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12 December 2020

p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation

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12 December 2020

Acetylation of tau inhibits its degradation and contributes to tauopathy

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12 December 2020

Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor

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12 December 2020

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

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12 December 2020

Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1

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12 December 2020

Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms

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12 December 2020

Modulation of steroid hormone receptor activity

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12 December 2020

Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity

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12 December 2020

CREB-binding protein sequestration by expanded polyglutamine

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12 December 2020

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Transcriptional activation and nuclear targeting signals of the human androgen receptor.

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12 December 2020

Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones

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12 December 2020

10.1523/JNEUROSCI.3958-11.2011

Identifiers

DOI

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1 July 2019

PMC publication ID

6088793

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1 July 2019

PubMed publication ID

22131404

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1 July 2019