Bacterial Protein Toll-Like-Receptor Agonists: A Novel Perspective on Vaccine Adjuvants. (Q64996665)

3 July 2019

2 references

2 October 2020

11 December 2020

Bacterial Protein Toll-Like-Receptor Agonists: A Novel Perspective on Vaccine Adjuvants. (English)

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3 July 2019

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2 October 2020

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11 December 2020

Sudeep Kumar

1

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3 July 2019

Raju Sunagar

series ordinal

2

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3 July 2019

Edmund Gosselin

series ordinal

3

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3 July 2019

publication date

29 May 2019

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3 July 2019

2 October 2020

11 December 2020

Frontiers in Immunology

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3 July 2019

2 October 2020

11 December 2020

10

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3 July 2019

page(s)

1144

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3 July 2019

Creative Commons Attribution 4.0 International

copyright license

2 references

2 October 2020

Improving vaccine performance with adjuvants

11 December 2020

cites work

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12 December 2020

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Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

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Regulation of phagosome maturation by signals from toll-like receptors

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Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type.

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Porin of Shigella dysenteriae enhances Toll-like receptors 2 and 6 of mouse peritoneal B-2 cells and induces the expression of immunoglobulin M, immunoglobulin G2a and immunoglobulin A

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Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy.

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Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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Toll-dependent selection of microbial antigens for presentation by dendritic cells

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response.

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12 December 2020

On regulation of phagosome maturation and antigen presentation

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Activation of dendritic cells and induction of CD4(+) T cell differentiation by aluminum-containing adjuvants

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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

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Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

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The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells

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The leucine-rich repeat structure.

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Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens

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Molecular and cellular signatures of human vaccine adjuvants.

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Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant

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Bordetella pertussis filamentous hemagglutinin delivered by mucosal routes enhances immunoglobulin levels in serum and mucosal fluids

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12 December 2020

Structures of the toll-like receptor family and its ligand complexes

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12 December 2020

Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors

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12 December 2020

Mechanism of action of licensed vaccine adjuvants

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12 December 2020

Porin of Shigella dysenteriae directly promotes toll-like receptor 2-mediated CD4+ T cell survival and effector function.

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12 December 2020

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

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12 December 2020

34 kDa MOMP of Shigella flexneri promotes TLR2 mediated macrophage activation with the engagement of NF-kappaB and p38 MAP kinase signaling.

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12 December 2020

The Protein Moiety of Brucella abortus Outer Membrane Protein 16 Is a New Bacterial Pathogen-Associated Molecular Pattern That Activates Dendritic Cells In Vivo, Induces a Th1 Immune Response, and Is a Promising Self-Adjuvanting Vaccine against Syste

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12 December 2020

Innate immune function of the neisserial porins and the relationship to vaccine adjuvant activity

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12 December 2020

Unmet needs in modern vaccinology: adjuvants to improve the immune response

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12 December 2020

Human airway epithelial cell responses to Neisseria lactamica and purified porin via Toll-like receptor 2-dependent signaling

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12 December 2020

Vaccine adjuvants: putting innate immunity to work

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12 December 2020

Flagellin as an adjuvant: cellular mechanisms and potential.

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TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo

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12 December 2020

An oral vaccine based on U-Omp19 induces protection against B. abortus mucosal challenge by inducing an adaptive IL-17 immune response in mice

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12 December 2020

Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist

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The structural biology of Toll-like receptors

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12 December 2020

Defending the mucosa: adjuvant and carrier formulations for mucosal immunity

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12 December 2020

Vaccination in the elderly

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12 December 2020

Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner

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12 December 2020

Outer membrane protein A (OmpA) of Shigella flexneri 2a links innate and adaptive immunity in a TLR2-dependent manner and involvement of IL-12 and nitric oxide

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12 December 2020

Beyond pattern recognition: five immune checkpoints for scaling the microbial threat

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12 December 2020

Vaxjo: a web-based vaccine adjuvant database and its application for analysis of vaccine adjuvants and their uses in vaccine development

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12 December 2020

The FomA porin from Fusobacterium nucleatum is a Toll-like receptor 2 agonist with immune adjuvant activity

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12 December 2020

The meningococcal adhesin NhhA provokes proinflammatory responses in macrophages via toll-like receptor 4-dependent and -independent pathways

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12 December 2020

Mycobacterium paratuberculosis CobT activates dendritic cells via engagement of Toll-like receptor 4 resulting in Th1 cell expansion.

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12 December 2020

Presentation of phagocytosed antigens by MHC class I and II.

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12 December 2020

Toll-like receptor 2-dependent activity of native major outer membrane protein proteosomes of Chlamydia trachomatis

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12 December 2020

Vaccine strategies to enhance immune responses in the aged

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12 December 2020

Outer membrane protein A (OmpA) from Shigella flexneri 2a: a promising subunit vaccine candidate

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12 December 2020

MHC class II antigen presentation by dendritic cells regulated through endosomal sorting

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12 December 2020

TLR2 and TLR4 signaling pathways are required for recombinant Brucella abortus BCSP31-induced cytokine production, functional upregulation of mouse macrophages, and the Th1 immune response in vivo and in vitro

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12 December 2020

Vaccines for the 21st century

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12 December 2020

The contribution of vaccination to global health: past, present and future

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12 December 2020

Targeting TLR2 for vaccine development

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12 December 2020

A potential protein adjuvant derived from Mycobacterium tuberculosis Rv0652 enhances dendritic cells-based tumor immunotherapy

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12 December 2020

Outer membrane protein A (OmpA) of Shigella flexneri 2a induces TLR2-mediated activation of B cells: involvement of protein tyrosine kinase, ERK and NF-κB.

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12 December 2020

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

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12 December 2020

Interaction of Bordetella pertussis filamentous hemagglutinin with human TLR2: identification of the TLR2-binding domain.

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12 December 2020

TLR4 mediates pneumolysin-induced ATF3 expression through the JNK/p38 pathway in Streptococcus pneumoniae-infected RAW 264.7 cells

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12 December 2020

Mycobacterium tuberculosis RpfE promotes simultaneous Th1- and Th17-type T-cell immunity via TLR4-dependent maturation of dendritic cells.

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12 December 2020

Molecular signatures of vaccine adjuvants

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12 December 2020

Vibrio cholerae porin OmpU mediates M1-polarization of macrophages/monocytes via TLR1/TLR2 activation

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12 December 2020

Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways

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12 December 2020

Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathway

1 reference

12 December 2020

The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation.

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12 December 2020

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake.

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12 December 2020

Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4.

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12 December 2020

Mycobacterium tuberculosis MymA is a TLR2 agonist that activate macrophages and a TH1 response

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12 December 2020

Bacterial flagellin-a potent immunomodulatory agent.

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12 December 2020

Estimated economic impact of vaccinations in 73 low- and middle-income countries, 2001-2020.

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12 December 2020

Mycobacterium tuberculosis ESAT6 induces IFN-β gene expression in Macrophages via TLRs-mediated signaling

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12 December 2020

Expression of TLR2 by Dendritic Cells Is Essential for DnaJ-ΔA146Ply-mediated Th1 Immune Response against Streptococcus pneumoniae.

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12 December 2020

Flagellin as a vaccine adjuvant.

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12 December 2020

Adjuvant strategies to improve vaccination of the elderly population

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12 December 2020

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

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12 December 2020

Edward Jenner's 1798 report of challenge experiments demonstrating the protective effects of cowpox against smallpox

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12 December 2020

Identifiers

DOI

10.3389/FIMMU.2019.01144

1 reference

3 July 2019

PMC publication ID

6549121

1 reference

3 July 2019

PubMed publication ID

31191528

1 reference

3 July 2019