Low density lipoprotein receptor adaptor protein 1 (Q6693000)

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mammalian protein found in Homo sapiens

LDLRAP1
low density lipoprotein receptor adapter protein 1
autosomal recessive hypercholesterolemia protein
LDL receptor adaptor protein

Language	Label	Description	Also known as
English	Low density lipoprotein receptor adaptor protein 1	mammalian protein found in Homo sapiens	LDLRAP1 low density lipoprotein receptor adapter protein 1 autosomal recessive hypercholesterolemia protein LDL receptor adaptor protein

Statements

1 reference

13 November 2019

UniProt protein ID

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5SW96

PTB/PI domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

AP-2 adaptor complex binding

determination method

clathrin adaptor activity

determination method

1 reference

9 May 2019

Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

phosphotyrosine residue binding

determination method

1 reference

9 May 2019

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

signaling adaptor activity

determination method

1 reference

9 May 2019

ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

protein binding

determination method

6 references

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

1 reference

9 May 2019

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

signaling receptor complex adaptor activity

determination method

1 reference

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

AP-1 adaptor complex binding

determination method

1 reference

9 May 2019

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

AP-1 adaptor complex

determination method

1 reference

16 July 2018

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5SW96&geneProductId=UniProtKB:Q5SW96

determination method

recycling endosome

determination method

1 reference

9 May 2019

The Adaptor Protein ARH Escorts Megalin to and through Endosomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

determination method

1 reference

9 May 2019

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

basal plasma membrane

determination method

1 reference

9 May 2019

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

cytoplasmic side of plasma membrane

determination method

1 reference

9 May 2019

The Adaptor Protein ARH Escorts Megalin to and through Endosomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

AP-2 adaptor complex

determination method

1 reference

16 July 2018

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5SW96&geneProductId=UniProtKB:Q5SW96

determination method

plasma membrane

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

clathrin-coated vesicle membrane

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

determination method

3 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

The Adaptor Protein ARH Escorts Megalin to and through Endosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

biological process

positive regulation of receptor-mediated endocytosis

determination method

1 reference

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

steroid metabolic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

receptor-mediated endocytosis involved in cholesterol transport

determination method

3 references

9 May 2019

Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

Molecular mechanisms of autosomal recessive hypercholesterolemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

lipid metabolism

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

receptor internalization

determination method

1 reference

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

amyloid precursor protein metabolic process

determination method

1 reference

9 May 2019

Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

receptor-mediated endocytosis

determination method

1 reference

9 May 2019

The Adaptor Protein ARH Escorts Megalin to and through Endosomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

positive regulation of cholesterol metabolic process

determination method

1 reference

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

regulation of protein binding

determination method

1 reference

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

positive regulation of signal transduction

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

low-density lipoprotein particle clearance

determination method

3 references

9 May 2019

Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

Molecular mechanisms of autosomal recessive hypercholesterolemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

membrane organization

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

determination method

3 references

9 May 2019

Restoration of LDL receptor function in cells from patients with autosomal recessive hypercholesterolemia by retroviral expression of ARH1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering in coated pits

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

9 May 2019

Molecular mechanisms of autosomal recessive hypercholesterolemia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

regulation of protein localization to plasma membrane

determination method

1 reference

9 May 2019

Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

cholesterol transport

determination method

1 reference

9 May 2019

The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

cellular response to cytokine stimulus

determination method

1 reference

9 May 2019

Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

positive regulation of vascular associated smooth muscle cell proliferation

determination method

1 reference

9 May 2019

Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

positive regulation of low-density lipoprotein particle clearance

determination method

1 reference

9 May 2019

Induction of MiR133a expression by IL-19 targets LDLRAP1 and reduces oxLDL uptake in VSMC.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5SW96

determination method

Gene Atlas image

PBB GE LDLRAP1 221790 s at fs.png
732 × 530; 11 KB

0 references

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5SW96

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363458

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363458

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

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Multilingual sites(0 entries)

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