The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages (Q71214319)

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17 October 2019

title

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages (English)

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17 October 2019

author name string

C Porcher

1

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17 October 2019

W Swat

2

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17 October 2019

K Rockwell

3

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17 October 2019

Y Fujiwara

4

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17 October 2019

F W Alt

5

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17 October 2019

S H Orkin

6

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17 October 2019

language of work or name

English

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publication date

1 July 1996

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17 October 2019

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17 October 2019

volume

86

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17 October 2019

page(s)

47-57

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17 October 2019

issue

1

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The SCL gene is formed from a transcriptionally complex locus

17 October 2019

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Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript

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The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif

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The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein

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Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma

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The Ikaros gene is required for the development of all lymphoid lineages

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Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

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Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins

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7 January 2021

Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins

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7 January 2021

Hematopoietic commitment during embryonic stem cell differentiation in culture

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Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein

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7 January 2021

lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

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RAG-1-deficient mice have no mature B and T lymphocytes

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Production of homozygous mutant ES cells with a single targeting construct

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A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

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A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

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7 January 2021

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

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7 January 2021

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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7 January 2021

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PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.

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7 January 2021

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Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene

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7 January 2021

MyoD or Myf-5 is required for the formation of skeletal muscle

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7 January 2021

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Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8689686%20AND%20SRC:MED&resulttype=core&format=json

17 October 2019

1 reference