GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet (Q73153297)

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1 November 2019

title

GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet (English)

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1 November 2019

author name string

Takashi Usui

1

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1 November 2019

Ryuta Nishikomori

2

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1 November 2019

Atsushi Kitani

3

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1 November 2019

Warren Strober

4

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1 November 2019

publication date

1 March 2003

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1 November 2019

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1 November 2019

volume

18

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1 November 2019

issue

3

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1 November 2019

page(s)

415-428

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T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

1 November 2019

cites work

1 reference

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7 January 2021

Gene microarrays reveal extensive differential gene expression in both CD4(+) and CD8(+) type 1 and type 2 T cells

1 reference

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7 January 2021

GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

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7 January 2021

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

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7 January 2021

Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.

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7 January 2021

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system

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7 January 2021

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

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7 January 2021

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

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7 January 2021

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

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7 January 2021

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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7 January 2021

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

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7 January 2021

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

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7 January 2021

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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7 January 2021

Impaired development of Th2 cells in IL-13-deficient mice.

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7 January 2021

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

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7 January 2021

Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction

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7 January 2021

The lineage decisions of helper T cells

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7 January 2021

Signaling and transcription in T helper development

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7 January 2021

T helper type 2 cell differentiation occurs in the presence of interleukin 12 receptor beta2 chain expression and signaling

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7 January 2021

BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling

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7 January 2021

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

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7 January 2021

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

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7 January 2021

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

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7 January 2021

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

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7 January 2021

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

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7 January 2021

A novel transcription factor, T-bet, directs Th1 lineage commitment

1 reference

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7 January 2021

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

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7 January 2021

Essential role of Stat6 in IL-4 signalling

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7 January 2021

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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7 January 2021

IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites

1 reference

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7 January 2021

Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene

1 reference

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7 January 2021

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

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7 January 2021

10.1016/S1074-7613(03)00057-8

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12648458%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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