Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice (Q73574759)

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5 November 2019

title

Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice (English)

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5 November 2019

5

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5 November 2019

author name string

Fang Bai

1

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5 November 2019

Jing Hua Xi

2

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5 November 2019

Eric F Wawrousek

3

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5 November 2019

Timothy P Fleming

4

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5 November 2019

language of work or name

English

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publication date

25 June 2003

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Journal of Biological Chemistry

5 November 2019

published in

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5 November 2019

volume

278

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5 November 2019

issue

38

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5 November 2019

page(s)

36876-36886

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Expression of the murine alpha B-crystallin gene is not restricted to the lens

5 November 2019

cites work

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alpha B subunit of lens-specific protein alpha-crystallin is present in other ocular and non-ocular tissues

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Alpha-crystallin can function as a molecular chaperone

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Alpha-crystallin/small heat shock protein has autokinase activity

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Ectopic expression of alpha B-crystallin in Chinese hamster ovary cells suggests a nuclear role for this protein

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alphaB-crystallin interacts with cytoplasmic intermediate filament bundles during mitosis

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AlphaB-crystallin phosphorylated at Ser-59 is localized in centrosomes and midbodies during mitosis

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The dephosphorylation of lens alpha-crystallin A chain

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Preferential expression of alpha B-crystallin in astrocytic elements of neuroectodermal tumors.

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Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts

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Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner

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Lens epithelial cells derived from alphaB-crystallin knockout mice demonstrate hyperproliferation and genomic instability

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The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress

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A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

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Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function

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hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells

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Cytosolic chaperonin is up-regulated during cell growth. Preferential expression and binding to tubulin at G(1)/S transition through early S phase

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Functions of p53 suppress critical consequences of damage and repair in the initiation of cancer

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Signaling to p53: breaking the MDM2-p53 circuit

21 January 2018

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p53 accumulates but is functionally impaired when DNA synthesis is blocked

21 January 2018

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The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

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An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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A p53-dependent mouse spindle checkpoint

21 January 2018

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

21 January 2018

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21 January 2018

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21 January 2018

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A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

21 January 2018

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The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression.

21 January 2018

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hADA3 is required for p53 activity

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

When checkpoints fail

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The mitotic spindle: a self-made machine

21 January 2018

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Chaperone activity of alpha B-crystallin suppresses tubulin aggregation through complex formation.

21 January 2018

1 reference

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Separation of fibres from the capsule enhances mitotic activity of human lens epithelium

21 January 2018

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Segregating sister genomes: the molecular biology of chromosome separation

21 January 2018

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Maintenance of genome stability in Saccharomyces cerevisiae

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M304010200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12826669%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference