Long-lasting binding of IT-066 to human histamine H2 receptor (Q73663097)

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5 November 2019

title

Long-lasting binding of IT-066 to human histamine H2 receptor (English)

1 reference

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5 November 2019

main subject

pibutidine hydrochloride

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ChEBI release 2020-05-28

H Otsuka

1

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5 November 2019

Y Fukushima

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M Tamai

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H Takahashi

4

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H Mori

5

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T Asano

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T Katsube

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K Ogawa

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T Kajiwara

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S I Ohkawa

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T Saitoh

11

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publication date

1 April 2000

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Digestive Diseases and Sciences

5 November 2019

published in

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volume

45

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5 November 2019

issue

4

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5 November 2019

page(s)

796-801

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Structure-activity characterization of an H2-receptor antagonist, 3-amino-4-[4-[4-(1-piperidinomethyl)-2-pyridyloxy]-cis-2-++ +butenylamino]- 3-cyclobutene-1,2-dione hydrochloride (T-066), involved in the insurmountable antagonism against histamine-

5 November 2019

cites work

1 reference

12 December 2020

Time-Dependent Interaction of a New H2-Receptor Antagonist, IT-066, with the Receptor in the Atria of Guinea Pig

1 reference

12 December 2020

H2-receptor antagonism by a novel compound IT-066 assessed from [14C]aminopyrine accumulation in rabbit parietal cells

1 reference

12 December 2020

Desensitization of canine histamine H2 receptor expressed in Chinese hamster ovary cells

1 reference

12 December 2020

Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action.

1 reference

12 December 2020

Molecular basis for the interaction of histamine with the histamine H2 receptor

1 reference

12 December 2020

Effects of the new H2-receptor antagonist 3-amino-4-[4- [4- (1-piperidinomethyl)-2-pyridyloxy]-cis-2-butenylamino]-3-cyclobutene-1, 2- dione hydrochloride on gastric acid secretion and ulceration.

1 reference

12 December 2020

Role of the C terminus in histamine H2 receptor signaling, desensitization, and agonist-induced internalization

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12 December 2020

The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation.

1 reference

12 December 2020

Molecular cloning of a gene encoding the histamine H2 receptor

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12 December 2020

Molecular cloning of the human histamine H2 receptor

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12 December 2020

Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells

1 reference

12 December 2020

Oligomer formation of histamine H2 receptors expressed in Sf9 and COS7 cells

1 reference

12 December 2020

Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex

1 reference

12 December 2020

Antisecretory and antilesional effect of a new histamine H2-receptor antagonist, IT-066, in rats

1 reference

12 December 2020

Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations

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12 December 2020