Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed (Q73721666)

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scientific article published on 01 May 2000

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English	Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed	scientific article published on 01 May 2000

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scholarly article

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6 November 2019

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed (English)

1 reference

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6 November 2019

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author name string

G J Peters

1

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6 November 2019

B van Triest

2

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6 November 2019

H H Backus

3

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6 November 2019

C M Kuiper

4

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6 November 2019

C L van der Wilt

5

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6 November 2019

H M Pinedo

6

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6 November 2019

publication date

1 May 2000

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6 November 2019

European Journal of Cancer

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6 November 2019

36

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6 November 2019

7

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916-924

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6 November 2019

Clinical relevance of biochemical modulation of 5-fluorouracil

1 reference

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7 January 2021

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Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group.

1 reference

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7 January 2021

based on heuristic

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‘Tomudex’ (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia

1 reference

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7 January 2021

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ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group

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https://api.crossref.org/works/10.1016%2FS0959-8049%2800%2900026-5

7 January 2021

based on heuristic

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

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7 January 2021

based on heuristic

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Cancer. p53, guardian of the genome

1 reference

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based on heuristic

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P53, cell cycle control and apoptosis: implications for cancer

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7 January 2021

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The proto-oncogene Bcl-2 and its role in regulating apoptosis

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Regulators of cell death

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7 January 2021

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Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

1 reference

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7 January 2021

based on heuristic

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p53 and WAF1 are induced and Rb protein is hypophosphorylated during cell growth inhibition by the thymidylate synthase inhibitor ZD1694 (Tomudex)

1 reference

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7 January 2021

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Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells

1 reference

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7 January 2021

based on heuristic

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Identification of an RNA binding site for human thymidylate synthase

1 reference

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7 January 2021

based on heuristic

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The role of thymidylate synthase as an RNA binding protein

1 reference

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7 January 2021

based on heuristic

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Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor protein

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Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines

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Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing

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Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism

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Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.

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Screening the p53 status of human cell lines using a yeast functional assay

1 reference

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Clinical and pathological associations with p53 tumour-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma

1 reference

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

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Identifiers

10.1016/S0959-8049(00)00026-5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785598%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10785598%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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