Beta-secretase 1 (Q737488)

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mammalian protein found in Homo sapiens
  • BACE1
  • transmembrane aspartic proteinase Asp2
  • beta-site APP cleaving enzyme 1
  • beta-site APP-cleaving enzyme
  • APP beta-secretase
  • memapsin-2
  • beta-secretase 1 precursor variant 1
  • aspartyl protease 2
  • asp 2
  • membrane-associated aspartic protease 2
  • Beta-site amyloid precursor protein cleaving enzyme 1
  • beta-secretase 1
  • ASP2
  • beta-site amyloid beta A4 precursor protein-cleaving enzyme
edit
Language Label Description Also known as
English
Beta-secretase 1
mammalian protein found in Homo sapiens
  • BACE1
  • transmembrane aspartic proteinase Asp2
  • beta-site APP cleaving enzyme 1
  • beta-site APP-cleaving enzyme
  • APP beta-secretase
  • memapsin-2
  • beta-secretase 1 precursor variant 1
  • aspartyl protease 2
  • asp 2
  • membrane-associated aspartic protease 2
  • Beta-site amyloid precursor protein cleaving enzyme 1
  • beta-secretase 1
  • ASP2
  • beta-site amyloid beta A4 precursor protein-cleaving enzyme

Statements

molecular function
protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme
GOA
curator
Alzheimers Project at University of Toronto
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
retrieved
8 April 2019
stated in
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IPI
cell component
early endosome
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IEA
retrieved
8 April 2019
stated in
BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
late endosome
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IEA
retrieved
8 April 2019
stated in
BACE is degraded via the lysosomal pathway
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
Golgi apparatus
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IEA
retrieved
8 April 2019
stated in
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))
GOA
curator
UniProt
UniProt protein ID
P56817
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56817
determination method
IBA
biological process
EC enzyme number
3.4.23.46
0 references
Gene Atlas image
PBB GE BACE1 217904 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

Microsoft Academic ID
2777749304
0 references
2910719675
0 references
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q737488&oldid=2022902616"