Identification of a tumor-derived p53 mutant with novel transactivating selectivity (Q73934794)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871862%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Identification of a tumor-derived p53 mutant with novel transactivating selectivity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871862%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Y Pan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871862%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

D S Haines

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871862%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

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publication date

1 June 2000

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871862%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10871862%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

19

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7 November 2019

issue

27

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7 November 2019

page(s)

3095-3100

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203663

7 November 2019

exact match

0 references

cites work

Suppression of human colorectal carcinoma cell growth by wild-type p53

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7 January 2021

mdm2 expression is induced by wild type p53 activity

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7 January 2021

c-Myc target gene specificity is determined by a post-DNAbinding mechanism

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mdm2-P2 transcript levels predict the functional activity of the p53 tumor suppressor in primary leukemic cells.

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7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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7 January 2021

Definition of a consensus binding site for p53

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WAF1, a potential mediator of p53 tumor suppression

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

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7 January 2021

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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7 January 2021

A transcriptionally active DNA-binding site for human p53 protein complexes

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7 January 2021

Physical and functional interaction between wild-type p53 and mdm2 proteins

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7 January 2021

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells

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7 January 2021

Oncogenic forms of p53 inhibit p53-regulated gene expression

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7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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7 January 2021

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

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7 January 2021

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

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7 January 2021

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

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7 January 2021

Analysis of p53 and mdm-2 expression in 18 patients with Sézary syndrome

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7 January 2021

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

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7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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7 January 2021

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

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A model for p53-induced apoptosis

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7 January 2021

Mutant p53: gain-of-function oncoproteins and wild-type p53 inactivators

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7 January 2021

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

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7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

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7 January 2021

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

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7 January 2021

p53-independent role of MDM2 in TGF-beta1 resistance

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7 January 2021

Interaction of p53 with its consensus DNA-binding site

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7 January 2021

The p53-mdm-2 autoregulatory feedback loop

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7 January 2021

p53 binds to a constitutively nucleosome free region of the mdm2 gene

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7 January 2021

Interaction between the retinoblastoma protein and the oncoprotein MDM2

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7 January 2021

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

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7 January 2021

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element

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7 January 2021

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

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7 January 2021

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

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7 January 2021